Organic Chemistry
Organic Chemistry
6th Edition
ISBN: 9781936221349
Author: Marc Loudon, Jim Parise
Publisher: W. H. Freeman
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Chapter 25, Problem 25.9P
Interpretation Introduction

(a)

Interpretation:

The given reaction is to be completed.

Concept Introduction:

Thioesters react with nucleophiles in acyl substitution reactions via addition-elimination mechanism. If the nucleophile is an amine, then the product formed in these reactions is an amide.

Interpretation Introduction

(b)

Interpretation:

It is to be explained why the reaction of the thioester and the amine is thermodynamically favorable under neutral conditions but the reaction is not observed in presence of an acid.

Concept introduction:

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