(a)
Interpretation:
The possibility of the given reaction to carry out through nucleophilic substitution reaction is to be stated.
Concept introduction:
(b)
Interpretation:
The possibility of the given reaction to carry out through nucleophilic substitution reaction is to be stated.
Concept introduction:
Carboxylic acids and its derivatives undergo nucleophilic acyl substitution. The reaction involves replacement of leaving group
(c)
Interpretation:
The possibility of the given reaction to carry out through nucleophilic substitution reaction is to be stated.
Concept introduction:
Carboxylic acids and its derivatives undergo nucleophilic acyl substitution. The reaction involves replacement of leaving group
(d)
Interpretation:
The possibility of the given reaction to carry out through nucleophilic substitution reaction is to be stated.
Concept introduction:
Carboxylic acids and its derivatives undergo nucleophilic acyl substitution. The reaction involves replacement of leaving group
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- It is typically very difficult to do a substitution reaction on an aromatic ring when the leaving group is flanked by two other bulky substituents. Moreover, in Section 22.3, we found that nucleophilic aromatic substitution requires strongly electron-withdrawing groups on the benzene ring. However, Pd-catalyzed coupling allows entry into such products. As examples, write the products of the following reactions and state which coupling reaction is being utilized.arrow_forwardArrange the following in order of decreasing reactivity to nucleophilic addition: ketone, aldehyde. Explain your logic.arrow_forwardIn electrophilic aromatic displacement reaction by drawing the structures of the compounds given belowexplain which products will be formed as a result of its reaction with the nitronium ion. methoxybenzene, benzoicacidearrow_forward
- Although chlorine is an electron withdrawing group, yet it is ortho-, para¬directing in electrophilic aromatic substitution reactions. Explain why it is SO?arrow_forwardProvide the curved-arrow mechanism to account for the following electrophilic aromatic substitution reaction. .CI Cl2 FeCl3arrow_forwardComplete the curved arrow notation and include the structure of the missing organic intermediate for the following steps of a nucleophilic aromatic substitution via an addition–elimination mechanism.arrow_forward
- What was the diene that was used to make this Diels-Alder reaction product? refluxarrow_forwardBased on the following groups Acid chloride, Amide, Ester a) Select the most reactive group towards nucleophilic acyl substitution reaction. b) Describe the reasons in question (a). c) Identify the group(s) that can been synthesized from acid chloride.arrow_forwardIn electrophilic aromatic substitution, a group attached to the aromatic ring does not affect ring reactivity. rightfalsearrow_forward
- What class of the reaction is the "synthesis of hexyI acetate reaction" an example of? What about the starting material suggest that it follows the reaction pathway?arrow_forwardIllustrate Devising a Synthesis with a Carbon–Carbon Bond- Forming Reaction ?arrow_forwardGive handwritten answer with explanationarrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage LearningOrganic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning