ACHIEVE:INTRO TO GENETIC ANALYSIS 1TERM
12th Edition
ISBN: 9781319401399
Author: Griffiths
Publisher: MAC HIGHER
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Chapter 2, Problem 89P
Summary Introduction
To determine: The inheritance pattern of the given pedigree chart.
Introduction: Different methods can be followed by different diseases to carry forward to the next generation. The inheritance pattern includes autosomal dominant, autosomal recessive, X-linked recessive, X-linked dominant, and Y-linked.
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The following pedigree shows the inheritance of a human disorder. Affected individuals are
shown with filled symbols.
II
III
2 3
5
Based on the pedigree, propose the least likely inheritance pattern of the disease among
autosomal dominance, autosomal recessive, X-linked dominance and X-linked recessive.
Your choice of answer can be impossible and possible. Explain your answer by giving the
evidence that supports or opposes each mode of inheritance. You can reconstruct the table
shown below and draw the pedigree in your answer script. Write the possible genotype of
each individual in the pedigree for each inheritance pattern proposed.
Mode of
Possibility
Explanations
Pedigree
inheritance
Autosomal
dominance
Autosomal
recessive
X-linked
dominance
X-linked
recessive
A woman knows that her mother is a carrier of Kartagener’s syndrome (an autosomal recessive disorder). The woman does not know if either she or her husband are carriers. The couple wants to have a child, but is worried about whether or not they could have a child with Kartagener’s syndrome. Should the couple seek the advice of a genetic counselor? In other words, is there a chance they could have an affected child? If there is a chance, please make sure your answer includes the specific parental genotypes necessary to make this possible.
7) The pedigree below traces the inheritance of alkaptonuria, a biochemical disorder. Does
alkaptonuria appear to be caused by a dominant or recessive allele? Is this allele autosomal or sex-
linked? Determine the probable genotypes for all the individuals in this pedigree.
Sandra
Daniel
George
Tom Sam Wilma Ann
Alan
Tina
Arlene
Christopher
Carla
Michael
Chapter 2 Solutions
ACHIEVE:INTRO TO GENETIC ANALYSIS 1TERM
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37PCh. 2 - Prob. 38PCh. 2 - Prob. 39PCh. 2 - Prob. 40PCh. 2 - Prob. 41PCh. 2 - Prob. 42PCh. 2 - Prob. 43PCh. 2 - Prob. 44PCh. 2 - Prob. 45PCh. 2 - Prob. 46PCh. 2 - Prob. 47PCh. 2 - Prob. 48PCh. 2 - Prob. 49PCh. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 - Prob. 52PCh. 2 - Prob. 53PCh. 2 - Prob. 54PCh. 2 - Prob. 55PCh. 2 - Prob. 56PCh. 2 - Prob. 56.1PCh. 2 - Prob. 56.2PCh. 2 - Prob. 56.3PCh. 2 - Prob. 56.4PCh. 2 - Prob. 56.5PCh. 2 - Prob. 56.6PCh. 2 - Prob. 56.7PCh. 2 - Prob. 56.8PCh. 2 - Prob. 56.9PCh. 2 - Prob. 56.10PCh. 2 - Prob. 56.11PCh. 2 - Prob. 56.12PCh. 2 - Prob. 56.13PCh. 2 - Prob. 56.14PCh. 2 - Prob. 56.15PCh. 2 - Prob. 57PCh. 2 - Prob. 58PCh. 2 - Prob. 59PCh. 2 - Prob. 60PCh. 2 - Prob. 61PCh. 2 - Prob. 62PCh. 2 - Prob. 63PCh. 2 - Prob. 64PCh. 2 - Prob. 65PCh. 2 - Prob. 67PCh. 2 - Prob. 68PCh. 2 - Prob. 69PCh. 2 - Prob. 70PCh. 2 - Prob. 71PCh. 2 - Prob. 72PCh. 2 - Prob. 73PCh. 2 - Prob. 74PCh. 2 - Prob. 75PCh. 2 - Prob. 76PCh. 2 - Prob. 77PCh. 2 - Prob. 78PCh. 2 - Prob. 79PCh. 2 - Prob. 80PCh. 2 - Prob. 81PCh. 2 - Prob. 82PCh. 2 - Prob. 83PCh. 2 - Prob. 84PCh. 2 - Prob. 85PCh. 2 - Prob. 86PCh. 2 - Prob. 87PCh. 2 - Prob. 88PCh. 2 - Prob. 89PCh. 2 - Prob. 90PCh. 2 - Prob. 91PCh. 2 - Prob. 1GSCh. 2 - Prob. 2GSCh. 2 - Prob. 3GS
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- Below is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions. Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3? If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?arrow_forwardPlease consider the following pedigree. Assume that people who marry in to the family do not carry the allele. Assume complete penetrance. I II III 3 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Based strictly on the characteristic patterns of inheritance that define the four different options in (a), give a definitive motivation for the most likely mode of inhertance.arrow_forwardRefer to the pedigree below which shows inheritance for achondroplasia (dwarfism), a dominantly inherited trait (denoted as D), which are the darkened circles and squares. Dwarfism (darkened shapes) are dominantly inherited, while normal height is recessively inherited (hh). Based on the pedigree, what is the correct genotype for individual #II-6? Dominant Autosomal Pedigree 2 II 2 3 II 1 2 3 6 9 10 Dd DD DD or Dd ddarrow_forward
- The pedigree below represents the inheritance of a rare genetic disorder (members joining the pedigree are not carriers). Consider the following pedigree and answer questions (i) to (vii) below. The allele descriptors are B/b. What is the mode of inheritance in this pedigree ? Y-linked inheritance X-linked recessive inheritance X-linked dominant inheritance Autosomal recessive inheritance Autosomal dominant inheritance What is the genotype of individual III-2 ? a) XbXb b) XBXB c) XBXb d) Bb e) bb What is the genotype of individual IV-3 ? a) XbXb b) XBXB c) XBXb d) Bb e) bb Individual IV-4 and an unaffected woman is planning a family. What is the probability that their first child will be phenotypically normal ? a) chance that the first child will be phenotypically normal. b) chance that the first child will be phenotypically normal. c) chance that the first female child will be phenotypically normal; all male children will be phenotypically normal. d) chance that the…arrow_forwardX‑linked, recessive diseases, such as hemophilia, are extremely rare in the population. However, many women are carriers and show no sign of the disease. The pedigree illustrates the inheritance of an X‑linked, recessive disease. Determine whether the unknown individuals are affected by the disease, unaffected by the disease, or carriers of the X‑linked recessive allele. Unaffected individuals are not carriers of the X‑linked recessive allele.arrow_forwardX-linked ichthyosis is an X-linked recessive trait that manifests in part as dry, scaly skin (“ichthy-” = fish or fish like). Suppose a couple are considering having a child together. Parent A is heterozygous for the ichthyosis allele while Parent B is hemizygous negative for the ichthyosis allele. What is the probability their child would be unafflicted with ichthyosis but be a carrier of the ichthyosis-causing allele? a.0% b.25% c.50% d.75% e.100%arrow_forward
- Sheree is referred to a genetic counselor because a cystic fibrosis (CF) test done as a routine part of her prenatal care indicated that she is a carrier of the most common mutant allele. Sheree is stunned, because no one in her family has the disease. She is 26 years old. The genetic counselor would most likely explain autosomal recessive inheritance and suggest that Sheree's husband be tested for the CF allele. explain autosomal dominant inheritance and suggest that Sheree's husband be tested for the CF allele. explain autosomal recessive inheritance and suggest that Sheree's parents be tested for the CF allele. advise Sheree to have amniocentesis to check the fetus for the CF genotype.arrow_forward3) You have sought a job at a human genetic counseling clinic. They gave you an aptitude test shown below. Answer the yes/no questions concerning each of the following pedigrees. Pedigree A: YES or NO Could this trait be inherited as a simple autosomal recessive? Could this trait be inherited as a simple autosomal dominant? Could this trait be inherited as a simple X-linked recessive? Could this trait be inherited as a simple X-linked dominant? Pedigree B: YES or NO Could this trait be inherited as a simple autosomal recessive? Could this trait be inherited as a simple autosomal dominant? Could this trait be inherited as a simple X-linked recessive? Could this trait be inherited as a simple X-linked dominant?arrow_forwardLook at the pedigree below and answer the following questions related to the human genetic trait depicted in this pedigree. 1. Indicate whether the pattern of inheritance associated with this human trait is most likely to be (i) rare X-linked recessive, (ii) sex-influenced, or (iii) sex-limited. You may assume that the gene is fully penetrant. Then, provide a specific reason that justifies your selection of this pattern of inheritance as the correct one, and also explain why each of the other two alternatives are not correct. As part of your answer, include the phenotypic ratio, including the sex of the offspring, that you would expect to find in each of the three possible scenarios.arrow_forward
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