Chapter 18, Problem 60SA

Summary Introduction

To explain:

The possible consequence of the inactivating mutation in RB1 (retinoblastoma), whichleadsto the inability of pRB(retinoblastoma protein) in bindingRBP2 (retinoblastoma binding protein2).

Introduction:

pRB is also known as the tumor suppressor protein. It is coded by the retinoblastoma tumor suppressor gene Rb. It is an antioncogene that defends the cell against cancer. It is also referred to as pocket protein because it consists of three members, namel, yb/p130, Rb/p105, andp107. Its main function is to inhibit cell proliferation and cell death.