Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 18, Problem 44RQ
Summary Introduction

To review:

The function of mismatch repair (MMR) in DNA (deoxyribonucleic acid) repair and the reason behind the onset of cancer in humans if MMR protein gets mutated.

Introduction:

Mismatch repair is a type of single-strand repair mechanism, which repairs helix distorting base mispairings that takes place because of the errors in replication proofreading. In mismatch repair mechanism, machinery is able to differentiate between old and newly synthesized daughter strands because of the methylation of the parental strand.

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9. Which one of the compounds below is the major organic product obtained from the following reaction sequence, starting with ethyl acetoacetate? 요요. 1. NaOCH2CH3 CH3CH2OH 1. NaOH, H₂O 2. H3O+ 3. A OCH2CH3 2. ethyl acetoacetate ii A 3. H3O+ OH B C D E
7. Only one of the following ketones cannot be made via an acetoacetic ester synthesis. Which one is it? Ph کہ A B C D E
2. Which one is the major organic product obtained from the following reaction sequence? HO A OH 1. NaOEt, EtOH 1. LiAlH4 EtO OEt 2. H3O+ 2. H3O+ OH B OH OH C -OH HO -OH OH D E .CO₂Et

Chapter 18 Solutions

Biochemistry: The Molecular Basis of Life

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