The reason for administering naproxen as its sodium salt has to be determined. Concept Introduction: Drugs are consumed orally as its salt form to increase the solubility of the drug and thus better absorption. Amine drugs are usually converted to its ammonium salt whereas carboxylic acids are converted to carboxylate salts. Naproxen: It is a type of which is used to decrease the pain, fever, stops blood from clotting and reduces inflammation. Naproxen is a weak acid and is consumed as sodium salt of naproxen.

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 17.6, Problem 17.5CIAP

Interpretation Introduction

Interpretation:

The reason for administering naproxen as its sodium salt has to be determined.

Concept Introduction:

Drugs are consumed orally as its salt form to increase the solubility of the drug and thus better absorption. Amine drugs are usually converted to its ammonium salt whereas carboxylic acids are converted to carboxylate salts.

Naproxen: It is a type of which is used to decrease the pain, fever, stops blood from clotting and reduces inflammation.

Naproxen is a weak acid and is consumed as sodium salt of naproxen.

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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 17.6, Problem 17.5CIAP

Interpretation Introduction

Interpretation:

The reason for administering naproxen as its sodium salt has to be determined.

Concept Introduction:

Drugs are consumed orally as its salt form to increase the solubility of the drug and thus better absorption. Amine drugs are usually converted to its ammonium salt whereas carboxylic acids are converted to carboxylate salts.

Naproxen: It is a type of which is used to decrease the pain, fever, stops blood from clotting and reduces inflammation.

Naproxen is a weak acid and is consumed as sodium salt of naproxen.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 17.6, Problem 17.5CIAP

Interpretation Introduction

Interpretation:

The reason for administering naproxen as its sodium salt has to be determined.

Concept Introduction:

Drugs are consumed orally as its salt form to increase the solubility of the drug and thus better absorption. Amine drugs are usually converted to its ammonium salt whereas carboxylic acids are converted to carboxylate salts.

Naproxen: It is a type of which is used to decrease the pain, fever, stops blood from clotting and reduces inflammation.

Naproxen is a weak acid and is consumed as sodium salt of naproxen.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 17.6, Problem 17.5CIAP

Interpretation Introduction