A detail mechanism for the formation of Z-Ala is to written, reason for the amino group act as the nucleophile preferentially over the carboxylate anion to be explained and the mechanism for formation of Fmoc-protected amino under the given condition is to be written. Concept introduction: The essence of the peptide of protein synthesis is formation of the amide function group by the reaction of an activated carboxylic acid derivative with an amine . The Fmoc (fluorenymethyloxycarbonyl) acts as a base-labile protecting group.

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 17, Problem 1LGP

Interpretation Introduction

Interpretation:

A detail mechanism for the formation of Z-Ala is to written, reason for the amino group act as the nucleophile preferentially over the carboxylate anion to be explained and the mechanism for formation of Fmoc-protected amino under the given condition is to be written.

Concept introduction:

The essence of the peptide of protein synthesis is formation of the amide function group by the reaction of an activated carboxylic acid derivative with an amine.

The Fmoc (fluorenymethyloxycarbonyl) acts as a base-labile protecting group.

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As we’ve discussed, a peptide bond is made when amino group of one amino acid combines with the carboxylic acid group of another amino acid (releasing a water molecule in the process). The C-N bond formed in this process is called a peptide bond. Peptide bonds have a few properties that might be unexpected. b) Another observation is that although the N-H of the peptide bond is able to serve as a H-bond donor the N atom of the peptide bond does not serve as an effective H-bond acceptor. Provide an explanation for this observation, using Lewis structures, VSEPR theory and/or valence bond theory as appropriate.c) It is also fairly accepted that while proteins undergo dynamic motions and conformational changes, and while R groups can freely rotate about Cα, it is generally not possible to freely rotate around a peptide bond. Please explain this observation, using a picture showing relevant orbitals on relevant atoms (your answer for part (a) might provide a useful basis for your reasoning…

Indicate whether each statement is true or false: (a) Fat molecules contain amide bonds. (b) Phosphoplipids can be zwitterions. (c) Phospholipids form bilayers in water in order to have their long hydrophobic tails interact favorably with each other, leaving their polar heads to the aqueous environment.

(a) Provide four distinct forms of phenylalanine. (b) Rank the solubility of these forms in water. (c) Explain your ranking.

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 17, Problem 1LGP

Interpretation Introduction

Interpretation:

A detail mechanism for the formation of Z-Ala is to written, reason for the amino group act as the nucleophile preferentially over the carboxylate anion to be explained and the mechanism for formation of Fmoc-protected amino under the given condition is to be written.

Concept introduction:

The essence of the peptide of protein synthesis is formation of the amide function group by the reaction of an activated carboxylic acid derivative with an amine.

The Fmoc (fluorenymethyloxycarbonyl) acts as a base-labile protecting group.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 17, Problem 1LGP

Interpretation Introduction

Interpretation:

A detail mechanism for the formation of Z-Ala is to written, reason for the amino group act as the nucleophile preferentially over the carboxylate anion to be explained and the mechanism for formation of Fmoc-protected amino under the given condition is to be written.

Concept introduction:

The essence of the peptide of protein synthesis is formation of the amide function group by the reaction of an activated carboxylic acid derivative with an amine.

The Fmoc (fluorenymethyloxycarbonyl) acts as a base-labile protecting group.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 17, Problem 1LGP

Interpretation Introduction