Chapter 16, Problem 68P

Interpretation Introduction

Interpretation:

The amino acid deleted in the mutation causing CF to a CTT deletion should be determined.

Concept Introduction:

The translation process is influenced by the codon usage and secondary structure of mRNA.

Cystic fibrosis (CF) results in the deletion of three nucleotides (CTT) from CFTR gene which stands for cystic fibrosis trans-membrane conductance regulator (CFTR) and includes cytosine (C) (last) of isoleucine 507 and the two thymidines (T) of phenylalanine 508 codons. This results in the loss of phenylalanine at the positionin the CFTR protein. This loss is expressed as