(a)
Interpretation:
The structure of the product obtained on reaction of acetyl chloride with anisole (methoxybenzene) in presence of
Concept introduction:
The reaction between acyl chloride with benzene in presence of
(b)
Interpretation:
The structure of the product obtained on reaction of
Concept introduction:
The reaction between ethylbenzene and chloromethane in presence of
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Organic Chemistry
- (b) A student wanted to synthesize methyl tert-butyl ether. He attempted the synthesis by adding sodium methoxide to tert-butyl chloride, but he obtained none of the desired product (1) (ii) Use an equation to show the product formed in this reaction Propose a suitable William ether synthetic route for methyl tert-butyl ether tach l.arrow_forward(b) Provide a stepwise mechanism for the bromination of nitrobenzene.arrow_forwardWrite structural formulas for the cyclohexadienyl cations formed from aniline (C6H5NH2) during(a) Ortho bromination (four resonance structures)(b) Meta bromination (three resonance structures)(c) Para bromination (four resonance structures)arrow_forward
- 3. Obtain acetophenone and acetaldehyde by reaction of glycols with periodic acid. Justify your answer with the reaction mechanism.arrow_forward(a) Given and Scara were given a task of synthesising (2-methylprop-1- enyl)cyclohexane 2 (A potential TB drug). After a brief discussion with each other, Given proposed Method A to synthesise 2 from cyclohexanecarbaldehyde 1 while Scara proposed Method B that started from hydroxymethylcyclohexane 3. When designing a synthetic route for drug molecule, you have to make sure the synthetic process is as efficient as possible (e.g. few synthetic steps, mostly making one product and more). THF A Ph Ph Ph B 3 1. PCC 2. isopropyl magnesium vromide 3. H₂SO4 100 °C OH Method B is not preferred synthetic route due to the number of steps involve (3 steps vs 1 step for Method A). What else is making method A unfavorable synthetic method? Use curly arrows to explain this effect. (Ctrl) -arrow_forward4. (A) A medicinal chemist wished to make a series of aromatic molecules bearing a ketone and thioether group with ortho, meta, or para relationships. To achieve this, they propose using nucleophilic aromatic substitution treating the corresponding ortho, meta, and para aryl chlorides with sodium ethanethiolate (NaSEt). Predict which of these reactions will likely work and which will likely fail. Provide a mechanistic explanation why. SET O NasEt EtS glagol Glal ol heat EtS target molecules EtS (B) Would the analogous reactions using EtMgBr instead of NaSEt be more or less likely to work? Explain why or why not. لمسلم EtMgBrarrow_forward
- (a) How will you obtain the following :(i) Benzaldehyde from Phenol (ii) Benzoic acid from Aniline(b) Give reasons :(i) Aldehydes are more reactive than ketones towards nucleophilic reagents.(ii) Electrophilic substitution in benzoic acid takes place at meta position.(iii) Carboxylic acids do not give the characteristic reactions of carbonyl group.arrow_forward(a) Given and Scara were given a task of synthesising (2-methylprop-1- envl)cyclohexane 2 (A potential TB drug). After a brief discussion with each other, Given proposed Method A to synthesise 2 from cyclohexanecarbaldehyde 1 while Scara proposed Method B that started from hydroxymethylcyclohexane 3. When designing a synthetic route for drug molecule, you have to make sure the synthetic process is as efficient as possible (e.g. few synthetic steps, mostly making one product and more). w 1 THF A Ph Ph Ph B 3 1. PCC 2. isopropyl magnesium vromide 3. H₂SO4 100 °C .OH After analyzing both of these methods, draw any one possible alkene product other than (2-methylprop-1-enyl)cyclohexane 2?arrow_forwardOutline methods for the preparation of acetophenone (phenyl methyl ketone) starting from the following: (a) Benzene (b) Bromobenzene Styrene (c) Methyl benzoate (d) Benzonitrilearrow_forward
- (c) Provide disadvantages of using water as solvent in synthesis. two advantages and two (d) Conventional bromination of Stilbene involves the use of mólecular bromine. Depict the reaction and propose a green alternative to this process with justification. trans-arrow_forward17. Outline all steps in a possible laboratory synthesis of each of the following from -butyl alcohol, using any inorganic reagents. Follow the general instructions in the box below. (a) n-butyl bromide (b) n-butyl iodide c) n-butyl hydrogen sulfate (d) sodium n-butoxide (e) butanenitrile, CH3CH₂CH₂CH₂CN (f) n-butyraldehyde, CH3CH₂CH₂CHO (g) n-butyric acid, CH3CH₂CH₂COOH (h) n-butane (i) n-butane-1-d, CH3CH₂CH₂CH₂D (j) n-octanearrow_forwardExplain how benzaldehyde and dimedone reacts with each other, and then with the aminotriazole to form compound 1a in the presence of an acid catalyst. Provide a detailed reaction mechanism and explanation.arrow_forward
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