Interpretation:
To predict that out of alcohol, water, and
Concept introduction:
Acid anhydride can react with water, alcohol and amine. When acid anhydride reacts with water it gives two equivalent of
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EBK ORGANIC CHEMISTRY
- Hydration of aldehydes and ketones can be catalyzed by acid or base. Bases catalyze hydration by: protonating the carbonyl oxygen making the carbonyl group more electrophilic employing hydroxide ion, which is a better nucleophile than water making the carbonyl group less electrophilic shifting the equilibrium position of the reaction to favor productsarrow_forwardAcetylcholine esterase is an important enzyme in neural synaptic signal transmission. It breaks down the neurotransmitter acetylcholine after it binds the acetylcholine receptor. Its active site has the same features used by serine proteases. Here is the reaction catalyzed by Acetylcholine esterase: Acetylcholine Choline OH Acetate + H Acetylcholine is an ester, while peptide bonds cleaved by proteases are amides. How should acetylcholine estease's mechanism accommodate this? This cannot be determined from the information presented in class and in this question. For amides, the amide nitrogen is deprotonate to make it more like an ester. The same mechanism cleaves deprotonated amides and esters. No changes are needed. The mechanism same works for esters and amides. Prior to cleavage, a transamination converts the ester to an amide. The esterase will make a covalent intermediate to an amine to create the amide to be cleaved.arrow_forwardFor the following reaction scheme, identify by drawing the reagents a, c, and d and the intermediate b that are formed in the synthesis of 2-phenylethanoic acid.arrow_forward
- Use the following reaction and information to answer a and b. 2ClO2(aq)+2OH-(aq)-->ClO-(aq)+Cl2-(aq)+H2O(l) [ClO2](M) [OH-](M) Initial rate (M/s) 0.060 0.030 0.0248 0.020 0.030 0.00276 0.020 0.090 0.00828 a. What is the order of this reaction in respect to ClO2, with respect to OH-, and the overall order? Assume the rate law has the form rate=k[ClO2]a[OH-]b b. What is the value of the rate constant? Include the units and why the unit make sense.arrow_forwardDraw the major organic product for the Friedel-Crafts acylation reaction.arrow_forwardShow how acid derivatives hydrolyze to carboxylic acids under either acidic or basicconditions. Explain why some acid derivatives (amides, for example) require muchstronger conditions for hydrolysis than other derivatives.arrow_forward
- Which of the following will produce ammonia upon hydrolysis? "NH2arrow_forwardThe addition of water to aldehydes and ketones occurs rapidly, although it is not thermodynamically favored. What would be the product for the reaction above? Hint: Think of the self-ionization of water and the polarity of the carbonyl group.arrow_forwardSubject-- chemistryarrow_forward
- Draw the major organic product of each of the following reactions.arrow_forwardOne acid–base classification defines a base as a substance that acts as a proton (H+H+) acceptor, and is also known as a Bronsted–Lowry base. All bases contain a non‑bonding pair of electrons. In each of the molecules, identify the atom that behaves only like a Bronsted–Lowry base. The atom in compound A that behaves only like a Bronsted–Lowry base is the nitrogen. the oxygen on the carbonyl. the oxygen bonded to hydrogen. the hydrogen bonded to oxygen.arrow_forward4. A CHEM 245 student wants to synthesize some ethylene glycol to use as antifreeze in his radiator this winter. He proposes the following reaction to his instructor, who quickly explains that this reaction won't work as proposed due to the student's choice of reagent. 1) NaH 2) H20 OH Но a) Why can't sodium hydride (NaH) be used as the nucleophile in the reaction above? b) Propose an alternate reagent that COULD be used with the ethylene oxide to successfully give the desired ethylene glycol product.arrow_forward
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