To arrange the given amides in decreasing order of reactivity towards acid-catalyzed hydrolysis reaction. Concept introduction: The normal reaction of an amide with water does not give good yield of product. As amides are least reactive carboxylic acid derivatives so to increase the reactivity of amides a mineral acid is added. The addition of acid increases the reactivity of amide by making more electrophilic carbonyl carbon and it also helps in the elimination of amine part from amide via protonating the amine group during reaction and make it a good leaving group. The reaction of water and amides in presence of acid gives a carboxylic acid as a product. The reaction eqaution is written as, The reactivity of amide also depends upon the leaving tendency of amine part from acyl group. The weaker the base better will be the leaving group. The basicity of amines is decreased by decreasing the electron density from nitrogen atom of amine.

Question

Want to see the full answer?

Answer 1

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 15.12, Problem 36P

Interpretation Introduction

Interpretation:

To arrange the given amides in decreasing order of reactivity towards acid-catalyzed hydrolysis reaction.

Concept introduction:

The normal reaction of an amide with water does not give good yield of product. As amides are least reactive carboxylic acid derivatives so to increase the reactivity of amides a mineral acid is added. The addition of acid increases the reactivity of amide by making more electrophilic carbonyl carbon and it also helps in the elimination of amine part from amide via protonating the amine group during reaction and make it a good leaving group.

The reaction of water and amides in presence of acid gives a carboxylic acid as a product. The reaction eqaution is written as,

The reactivity of amide also depends upon the leaving tendency of amine part from acyl group. The weaker the base better will be the leaving group. The basicity of amines is decreased by decreasing the electron density from nitrogen atom of amine.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Which of the following has the largest standard molar entropy, S° (298.15 K) He H2 NaCl KBr Hg

Which of the following is true for a particular reaction if ∆G° is -40.0 kJ/mol at 290 K and –20.0 kJ/mol at 390 K?

What is the major product of the following reaction? O O OH OH 1. BH 2. H₂O₂, NaOH OH OH

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 15.12, Problem 36P

Interpretation Introduction

Interpretation:

To arrange the given amides in decreasing order of reactivity towards acid-catalyzed hydrolysis reaction.

Concept introduction:

The normal reaction of an amide with water does not give good yield of product. As amides are least reactive carboxylic acid derivatives so to increase the reactivity of amides a mineral acid is added. The addition of acid increases the reactivity of amide by making more electrophilic carbonyl carbon and it also helps in the elimination of amine part from amide via protonating the amine group during reaction and make it a good leaving group.

The reaction of water and amides in presence of acid gives a carboxylic acid as a product. The reaction eqaution is written as,

The reactivity of amide also depends upon the leaving tendency of amine part from acyl group. The weaker the base better will be the leaving group. The basicity of amines is decreased by decreasing the electron density from nitrogen atom of amine.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 15.12, Problem 36P

Interpretation Introduction

Interpretation:

To arrange the given amides in decreasing order of reactivity towards acid-catalyzed hydrolysis reaction.

Concept introduction:

The normal reaction of an amide with water does not give good yield of product. As amides are least reactive carboxylic acid derivatives so to increase the reactivity of amides a mineral acid is added. The addition of acid increases the reactivity of amide by making more electrophilic carbonyl carbon and it also helps in the elimination of amine part from amide via protonating the amine group during reaction and make it a good leaving group.

The reaction of water and amides in presence of acid gives a carboxylic acid as a product. The reaction eqaution is written as,

The reactivity of amide also depends upon the leaving tendency of amine part from acyl group. The weaker the base better will be the leaving group. The basicity of amines is decreased by decreasing the electron density from nitrogen atom of amine.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 15.12, Problem 36P

Interpretation Introduction