Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 15, Problem 19P
Provide a description of the mechanistic roles of transcription factors and chromatin-modifying and chromatin-remodeling enzymes in the control of eukaryotic geneexpression.
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Design a transcriptional circuit that regulates the expression of β-galactosidase in a eukaryoticcell, such that the enzyme is produced in the presence of lactose and repressed in the absenceof lactose. Use at least one of the following elements: histone acetyltransferase, histonedeacetylase, chromatin remodeling complex
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LO43 Identify the levels at which gene expression can be regulated in prokaryotes and eukaryotes
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Chapter 15 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 15 - 13.1 Devoting a few sentences to each, describes...Ch. 15 - 13.2 Describe and give an example (real or...Ch. 15 - What is meant by the term chromatin remodeling?...Ch. 15 - 13.4 What general role does acetylation of histone...Ch. 15 - 13.5 Describe the roles of writers, readers, and...Ch. 15 - Outline the roles of RNA in eukaryotic gene...Ch. 15 - 13.7 What are the roles of the Polycomb and...Ch. 15 - Most biologists argue that the regulation of gene...Ch. 15 - Compare and contrast the transcriptional...Ch. 15 - The term heterochromatin refers to heavily...
Ch. 15 - 13.11 Compare and contrast promoters and enhancers...Ch. 15 - 13.12 What are the different chromatin...Ch. 15 - 13.13 Define epigenetics, and provide examples...Ch. 15 - What is one proposed role for lncRNAs?Ch. 15 - 13.17 A hereditary disease is inherited as an...Ch. 15 - Prob. 16PCh. 15 - A gene expressed in long muscle of the mouse is...Ch. 15 - The consequences of four deletions from the region...Ch. 15 - Provide a description of the mechanistic roles of...Ch. 15 - 13.20 A muscle enzyme called ME is produced by...Ch. 15 - 21. A muscle protein in mouse is produced through...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Identify the mechanisms of transcriptional,posttranscriptional, and translational control of geneexpression.arrow_forwardname TWO mechanisms of control of gene expression that are only used by eukaryotes and discuss why each of those mechanisms wouldn’t be possible in prokaryotes.arrow_forwardSuppose you had isolated a new transcription factor and wanted to know which genes this protein might regulate. Is there any way that you could use a cDNA microarray of the type shown in the picture to approach this question?arrow_forward
- Enhancers are sequences that affect the initiation of the transcription of genes that are hundreds or thousands of nucleotides away. Transcriptional activator proteins that bind to enhancers usually interact directly with transcription factors at promoters by causing the intervening DNA to loop out. An enhancer of bacteriophage T4 does not function by looping of the DNA (D. R. Herendeen et al. 1992. Science 256:1298–1303). Propose some mechanisms other than DNA looping by which this enhancer might affect transcription at a gene thousands of nucleotides awayarrow_forwardRegarding eukaryotic genes, it is correct to state that: a) Distal enhancer-like elements decrease the intensity of gene transcription activation b) Mutations in intronic regions of a gene can alter the levels of its corresponding protein c) They are regulated only by promoter regions, being activated or repressed by the presence of transcription factors d) The junctions of exons and introns are recognized by splicing factors, which guarantee the production of the same mRNA regardless of cell type. e) Activator and repressor proteins bind to the coding region of genes, regulating the intensity of their transcriptionarrow_forwardChromatin Immunoprecipitation (ChIP) experiments enable researchers to measure the levels of transcription factors, coactivators/corepressors and chromatin remodeling complexes on a specific gene in cells. In the ChIP experiment below, the recruitment of the transcription factor NfkB, Histone Deacetylase Complex (HDAC3) and p300/CBP complex to the Interleukin 12 (IL12) gene at various times (0, 30, 60 and 120 min) after treating cells with LPS are measured. Does LPS stimulate or inhibit transcription of the IL12 gene based on the recruitment of factors to the IL12 gene. Justify your answer by explaining the state of the gene before LPS and after LPS treatment (limit 5-6 sentences).arrow_forward
- Compare the control of gene regulation in eukaryotes and prokaryotes at the level of initiation of transcription. How do the regulatory mechanisms work? What are the similarities and differences in these two types of organisms in terms of the specific components of the regulatory mechanisms? Address how the differences or similarities relate to the biological context of the control of gene expression.arrow_forwardGlenn Croston and his colleagues studied the relation between chromatin structure and transcription activity. In one set of experiments, they measured the level of in vitro transcription of a Drosophila gene by RNA polymerase II in the presence of DNA and various combinations of histone proteins (G. E. Croston et al. 1991. Science 251:643–649). First, they measured the level of transcription of naked DNA, with no associated histone proteins. Then they measured the level of transcription after nucleosome octamers (without H1) were added to the DNA. The addition of the octamers caused the level of transcription to drop by 50%. When both nucleosome octamers and H1 proteins were added to the DNA, transcription was greatly repressed, dropping to less than 1% of that obtained with naked DNA, as shown in the table below. GAL4-VP16 is a protein that binds to the DNA of certain eukaryotic genes. When GAL4-VP16 is added to DNA, the level of transcription by RNA polymerase II is greatly elevated.…arrow_forwardDiscuss all the different ways and mechanisms that eukaryotes use to regulate gene expression.arrow_forward
- In a mutant mouse, it was discovered that a gene "W" is moved from its original chromosomal locus to the telomere region, where chromatin is packed into heterochromatin. Given what we have learned about eukaryotic gene regulation, can you speculate how the expression of gene W in the new mouse line would be changed as compare to the normal mouse? Question 18 options: elevated in the mutant mouse than in the wild-type mouse. cannot be determined. reduced in the mutant mouse than in the wild-type mouse. no change in the mutant mouse as compared to the wild-type mouse.arrow_forwardName four control points of regulation of eukaryotic gene expression, and where they occur in the cell.arrow_forwardThere are similarities and differences during regulation of gene expression in both prokaryotes and eukaryotes. Promoters, transcription factors and RNA polymerase are essential elements in transcription but their properties and function may differ.a) Predict the outcome or consequences of mRNA transcription by RNA polymerase II in eukaryote without the presence of transcription factors (TF).arrow_forward
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