Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 15, Problem 10P
The term heterochromatin refers to heavily condensed regions of chromosomes that are largely devoid of genes. Since few genes exist in those regions, they almost never decondense for transcription. At what point during the cell cycle would you expect to observe the decondensation of heterochromatic regions? Why?
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The interphase is the part of the eukaryotic cell cycle that is most transcriptionally active. Gene regulation during this phase involves changes in the chromatin.
a) What is chromatin?
b) How can the chromatin structure change?
Consider the figure beow, which depicts chromatin within the neucleus of a eukaryotic cell.
nucleus
O The letter A indicates regions of a single chromosome which are not expressed, and the letter B indicates
regions of a single chromosome which are expressed.
O Both answer choice A and answer choice B are correct.
The letter A indicates regions of a single chromosome which are condensed and attached to the nuclear
lamina, and the letter B indicates regions of a single chromosome which are partially decondensed.
O Answer choices A, B and C are all correct.
O The letter A represents repressed TADS, and the letter B represents active TADS.
What is the function of a centromere? At what stage of the cellcycle would you expect the centromere to be the most important?
Chapter 15 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 15 - 13.1 Devoting a few sentences to each, describes...Ch. 15 - 13.2 Describe and give an example (real or...Ch. 15 - What is meant by the term chromatin remodeling?...Ch. 15 - 13.4 What general role does acetylation of histone...Ch. 15 - 13.5 Describe the roles of writers, readers, and...Ch. 15 - Outline the roles of RNA in eukaryotic gene...Ch. 15 - 13.7 What are the roles of the Polycomb and...Ch. 15 - Most biologists argue that the regulation of gene...Ch. 15 - Compare and contrast the transcriptional...Ch. 15 - The term heterochromatin refers to heavily...
Ch. 15 - 13.11 Compare and contrast promoters and enhancers...Ch. 15 - 13.12 What are the different chromatin...Ch. 15 - 13.13 Define epigenetics, and provide examples...Ch. 15 - What is one proposed role for lncRNAs?Ch. 15 - 13.17 A hereditary disease is inherited as an...Ch. 15 - Prob. 16PCh. 15 - A gene expressed in long muscle of the mouse is...Ch. 15 - The consequences of four deletions from the region...Ch. 15 - Provide a description of the mechanistic roles of...Ch. 15 - 13.20 A muscle enzyme called ME is produced by...Ch. 15 - 21. A muscle protein in mouse is produced through...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- The picture below depicts electron micrographs of the major levels of chromatin structure. Match each of the listed conditions with the most likely levels of chromatin structure under that condition.arrow_forwardWhat is chromatin condensation?arrow_forwardFigure 3.7 shows a syncytial Drosophila embryo, a single large cell that can contain hundreds or even thousands of nuclei. Each round of nuclear division can occur rapidly, sometimes as quickly as 10 minutes. These rapid divisions do not require all the stages seen in a normal cell cycle. Which stages (G1, S, G, mitosis, cytokinesis) are dispensable and which are not? Explain.arrow_forward
- One change observed at the centrosomes early in mitosis is an increase in the number of γ-TURCcomplexes (which contain γ-tubulin.).How does the presence of γ-tubulin affect the balance between microtubule assembly & disassembly? Why might having more of it present in the centrosomal region be beneficial in the spindle assembly process?arrow_forwardWhich of the following statements most accurately represent chromatin state and transcription? Group of answer choices 1.Histone deacetylases promote closed chromatin and result in repressed transcription 2.Open chromatin is associated with hypoacetylation and has high levels of transcription 3.Histone acetyltransferases result in hypoacetylation and high levels of transcription 4.Hyperacetylation is associated with closed chromatin and low levels of transcriptionarrow_forwardIn which phases of the cell cycle would you expect double-strand break repair and nonhomologous end joining to occur and why?arrow_forward
- Which of the following represents the order of increasingly higher levels of organization of chromatin? Select one: O a. looped domain, nucleosome, 30-nm chromatin fiber O b. 30-nm chromatin fiber, nucleosome, looped domain C. nucleosome, looped domain, 30-nm chromatin fiber O d. looped domain, 30-nm chromatin fiber, nucleosome nucleosome, 30-nm chromatin fiber, looped domain е.arrow_forwardA cell inherits a mutation in a gene that results in a transcription factor, called NF-kB, constantly being in its active conformation. When active, NF-kB stimulates the expression of cyclins that promote progression of the cell cycle, regardless of other conditions. As a result of this mutation, how would this cell's phenotype be affected by this mutation? A) This cell would have a cancer phenotype B) This cell would grow larger in size, but would never divide C) This cell would likely undergo apoptosis D) This cell would not duplicate its chromosomes .arrow_forwardDefine the following terms: a. chromosome b. chromatinarrow_forward
- How can the chromatin structure change?arrow_forward(a)Discuss or explain the consequences for a cell if the chromatin could not be remodeled. (b) Does the action of the telemorase enzyme contradict the central dogma of molecular biology? why or why not?arrow_forwardIn the tracking chromosomal DNA movement through mitosis experiment, how many chromosomes did each of your daughter cells contain? Why is it important for each daughter cell to contain information identical to the parent cell? How often do human skin cells divide? Why might that be? Compare this rate to how frequently human neurons divide. What do you notice?arrow_forward
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