Whether the molecule acetoacetyl CoA is a C 2 , C 4 , C 6 or C 8 molecule has to be determined. Concept introduction: Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

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Q4: Rank the relative nucleophilicity of halide ions in water solution and DMF solution, respectively. F CI Br | Q5: Determine which of the substrates will and will not react with NaSCH3 in an SN2 reaction to have a reasonable yield of product. NH2 Br Br Br OH Br

Answer 1

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 14, Problem 14.71EP

(a)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetyl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(b)

Interpretation Introduction

Interpretation:

Whether the molecule 3-hydroxy-3-methylglutaryl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(c)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(d)

Interpretation Introduction

Interpretation:

Whether the molecule β-hydroxybutyrate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

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Q4: Rank the relative nucleophilicity of halide ions in water solution and DMF solution, respectively. F CI Br | Q5: Determine which of the substrates will and will not react with NaSCH3 in an SN2 reaction to have a reasonable yield of product. NH2 Br Br Br OH Br

Q7: Rank the following groups in order of basicity, nucleophilicity, and leaving group ability. a) H₂O, OH, CH3COOT b) NH3, H₂O, H₂S

Q8: Rank the following compounds in order of increasing reactivity in a nucleophilic substitution reaction with CN as the nucleophile. Br A B NH2 LL F C D OH CI LLI E Q9: Complete the missing entities for following reactions (e.g., major product(s), reactants, and/or solvents) for the SN2 reactions to occur efficiently. Include curved-arrow mechanism for reactions a) to d). a) H "Cl D + -OCH 3 Page 3 of 5

Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 14, Problem 14.71EP

(a)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetyl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(b)

Interpretation Introduction

Interpretation:

Whether the molecule 3-hydroxy-3-methylglutaryl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(c)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(d)

Interpretation Introduction

Interpretation:

Whether the molecule β-hydroxybutyrate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

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Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 14, Problem 14.71EP

(a)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetyl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(b)

Interpretation Introduction

Interpretation:

Whether the molecule 3-hydroxy-3-methylglutaryl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(c)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(d)

Interpretation Introduction

Interpretation:

Whether the molecule β-hydroxybutyrate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

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Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 14, Problem 14.71EP

(a)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetyl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(b)

Interpretation Introduction

Interpretation:

Whether the molecule 3-hydroxy-3-methylglutaryl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(c)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(d)

Interpretation Introduction

Interpretation:

Whether the molecule β-hydroxybutyrate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

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Answer 5

Chapter 14, Problem 14.71EP

(a)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetyl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(b)

Interpretation Introduction

Interpretation:

Whether the molecule 3-hydroxy-3-methylglutaryl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(c)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

(d)

Interpretation Introduction

Interpretation:

Whether the molecule β-hydroxybutyrate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

Answer 6

Chapter 14, Problem 14.71EP

(a)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetyl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

Answer 7

Chapter 14, Problem 14.71EP

(a)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetyl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

Answer 8

(b)

Interpretation Introduction

Interpretation:

Whether the molecule 3-hydroxy-3-methylglutaryl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

Answer 9

(b)

Interpretation Introduction

Interpretation:

Whether the molecule 3-hydroxy-3-methylglutaryl CoA is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

Answer 10

(c)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

Answer 11

(c)

Interpretation Introduction

Interpretation:

Whether the molecule acetoacetate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

Answer 12

(d)

Interpretation Introduction

Interpretation:

Whether the molecule β-hydroxybutyrate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

Answer 13

(d)

Interpretation Introduction

Interpretation:

Whether the molecule β-hydroxybutyrate is a C₂, C₄, C₆ or C₈ molecule has to be determined.

Concept introduction:

Ketone bodies are water-soluble molecules which are synthesized from acetyl CoA through the process of ketogenesis. Ketogenesis occurs in the mitochondria of the liver cells. The initial reactants are the molecules of acetyl CoA which are produced by the β-oxidation of fatty acid molecules. Ketone bodies are generally produced when the amount of acetyl CoA in the body is much larger than the amount of oxaloacetate. This happens due to the carbohydrate-lipid imbalance in the body caused by much smaller intake of food rich in carbohydrates, or inefficient processing of glucose by the body.

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Ch. 14.1 - Which of the following statements about digestion...Ch. 14.1 - Prob. 2QQ Ch. 14.1 - The major function of bile released during...Ch. 14.1 - The two major products of triacylglycerol...Ch. 14.1 - Prob. 5QQ Ch. 14.2 - Hormone-sensitive lipase needed for...Ch. 14.2 - Prob. 2QQ Ch. 14.2 - Which of the following is not a product of...Ch. 14.3 - Prob. 1QQ Ch. 14.3 - What is the intermediate compound in the two-step...

Solution Summary: The author explains that acetoacetyl CoA is a water-soluble molecule synthesized from it through the process of ketogenesis.

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