Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Videos
Textbook Question
Chapter 12, Problem 17QP
The following family has a history of inherited breast cancer. Betty (grandmother) does not carry the gene. Don, her husband, does. Don’s mother and sister had breast cancer. One of Betty and Don’s daughters (Sarah) has breast cancer; the other (Karen) does not. Sarah’s daughters are in their 30s. Dawn, 33, has breast cancer; Debbie, 31, does not. Debbie is wondering if she will get the disease because she looks like her mother. Dawn is wondering if her 2-year-old daughter (Nicole) will get the disease.
- a. Draw a pedigree indicating affected individuals and identify all individuals.
- b. What is the most likely mode of inheritance of this trait?
- c. What are Don’s genotype and
phenotype ? - d. What is the genotype of the unaffected women (Betty and Karen)?
- e. A genetic marker has been found that maps very close to the gene. Given the following marker data for chromosomes 4 and 17, which chromosome does this gene map to?
- f. Using the same genetic marker, Debbie and Nicole were tested. The results are shown in the following figure. Based on their genotypes, is either of them at increased risk for breast cancer?
Expert Solution & Answer
Trending nowThis is a popular solution!
Students have asked these similar questions
Imagine you are a botanist. Below are characteristics of a never-before described plant species recently identified as part of the ‘All Taxa Biodiversity Inventory’ (ATBI).
Field Notes: Specimen collected from shaded area along stream in South Cumberland State Park (Grundy County, TN).
Laboratory Analysis:
Body: Large leaves emerging from underground rhizome.
Size: 63 cm
Chromosomal Analysis: Plant body is diploid—chromosome number of 44.
Lignin test: Positive
Cuticle: Present
Leaves: Present—large with branched veins. Underside has sori (containing haploid spores).
Roots: Present—branch from the inside.
Stem: Present—vascular tissue (xylem & phloem) present.
Life History: Diploid sporophyte dominant generation. Haploid spores germinate into heart-shaped, haploid, gametophyte. Water required for fertilization; no seed is produced. Diploid zygote develops into sporophyte.
Explain which domain, kingdom and phylum you believe this plant should be classified…
CUÁ
Glycine
A C C
Newly formed molecule
Glycine Arginine Proline
Alanine
A C C
CC G
GGAUUGGUGGGGC
Structure X
I
mRNA
Adaptations to a Changing Environment
Why is it necessary for organisms to have the ability to adapt?
Why is the current environment making it difficult for organisms like the monarch butterfly to adapt?
Explain how organisms develop adaptations.
Chapter 12 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 12.10 - If improved diagnostic tests are developed from...Ch. 12.10 - If you had cancer, would you donate tissue samples...Ch. 12.10 - Prob. 1GRCh. 12.10 - Another model, the random model, proposes that any...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Mike was referred for genetic counseling because...Ch. 12 - Theodor Boveri predicted that malignancies would...Ch. 12 - Distinguish between a familial and a sporadic...Ch. 12 - Benign tumors: a. are noncancerous growths that do...
Ch. 12 - Prob. 4QPCh. 12 - Prob. 5QPCh. 12 - Prob. 6QPCh. 12 - Prob. 7QPCh. 12 - Prob. 8QPCh. 12 - What is the difference between a proto-oncogene...Ch. 12 - Distinguish between dominant inheritance and...Ch. 12 - Describe the likelihood of developing bilateral...Ch. 12 - Prob. 12QPCh. 12 - The search for the BRCA1 breast cancer gene...Ch. 12 - What are the roles of cellular proto-oncogenes,...Ch. 12 - Which of the following mutations will result in...Ch. 12 - Prob. 16QPCh. 12 - The following family has a history of inherited...Ch. 12 - You are in charge of a new gene therapy clinic....Ch. 12 - Prob. 19QPCh. 12 - Can you postulate a reason or reasons why children...Ch. 12 - Prob. 21QPCh. 12 - In Section 12-1, Julie is concerned that she may...Ch. 12 - Prob. 23QPCh. 12 - What are some factors that epidemiologists have...Ch. 12 - Smoking cigarettes has been shown to be associated...Ch. 12 - Prob. 26QPCh. 12 - Studies have shown that there are significant...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Artificial Selection: Explain how artificial selection is like natural selection and whether the experimental procedure shown in the video could be used to alter other traits. Why are quail eggs useful for this experiment on selection?arrow_forwardDon't give AI generated solution otherwise I will give you downwardarrow_forwardHello, Can tou please help me to develope the next topic (in a esquematic format) please?: Function and Benefits of Compound Microscopes Thank you in advance!arrow_forward
- Identify the AMA CPT assistant that you have chosen. Explain your interpretation of the AMA CPT assistant. Explain how this AMA CPT assistant will help you in the future.arrow_forwardwhat is the difference between drug education programs and drug prevention programsarrow_forwardWhat is the formula of Evolution? Define each item.arrow_forward
- Define the following concepts from Genetic Algorithms: Mutation of an organism and mutation probabilityarrow_forwardFitness 6. The primary theory to explain the evolution of cooperation among relatives is Kin Selection. The graph below shows how Kin Selection theory can be used to explain cooperative displays in male wild turkeys. B When paired, subordinant males increase the reproductive success of their solo, dominant brothers. 0.9 C 0 Dominant Solo EVOLUTION Se, Box 13.2 © 2023 Oxford University Press rB rB-C Direct Indirect Fitness fitness fitness gain Subordinate 19 Fitness After A. H. Krakauer. 2005. Nature 434: 69-72 r = 0.42 Subordinant Dominant a) Use Hamilton's Rule to show how Kin Selection can support the evolution of cooperation in this system. Show the math. (4 b) Assume that the average relatedness among male turkeys in displaying pairs was instead r = 0.10. Could kin selection still explain the cooperative display behavior (show math)? In this case, what alternative explanation could you give for the behavior? (4 pts) 7. In vampire bats (pictured below), group members that have fed…arrow_forwardExamine the following mechanism and classify the role of each labeled species in the table below. Check all the boxes that applyarrow_forward
- 1. Define and explain the two primary evolutionary consequences of interspecific competitionarrow_forward2 A linear fragment of DNA containing the Insulin receptor gene is shown below, where boxes represent exons and lines represent introns. Assume transcription initiates at the leftmost EcoRI site. Sizes in kb are indicated below each segment. Vertical arrows indicate restriction enzyme recognition sites for Xbal and EcoRI in the Insulin receptor gene. Horizontal arrows indicate positions of forward and reverse PCR primers. The Horizontal line indicates sequences in probe A. Probe A EcoRI Xbal t + XbaI + 0.5kb | 0.5 kb | 0.5 kb | 0.5kb | 0.5 kb | 0.5 kb | 1.0 kb EcoRI On the gel below, indicate the patterns of bands expected for each DNA sample Lane 1: EcoRI digest of the insulin receptor gene Lane 2: EcoRI + Xbal digest of the insulin receptor gene Lane 3: Southern blot of the EcoRI + Xbal digest insulin receptor gene probed with probe A Lane 4: PCR of the insulin receptor cDNA using the primers indicated Markers 6 5 4 1 0.5 1 2 3 4arrow_forward4. (10 points) woman. If both disease traits are X-linked recessive what is the probability A man hemizygous for both hemophilia A and color blindness mates with a normal hemophilia A nor colorblindness if the two disease genes show complete that a mating between their children will produce a grandson with neither a. linkage? (5 points) that a mating between their children will produce a grandson with both hemophilia A and colorblindness if the two disease genes map 40 cM apart? (5 points)arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
What are Mutations and what are the different types of Mutations?; Author: Science ABC;https://www.youtube.com/watch?v=I16YlE8qTBU;License: Standard youtube license