EBK GENETICS: FROM GENES TO GENOMES
EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
bartleby

Concept explainers

bartleby

Videos

Textbook Question
Book Icon
Chapter 11, Problem 39P

Figure 11.26 portrayed the analysis of Miller syndrome through the sequencing of four complete genomes: those of a brother and sister both affected by the disease, and of both their parents.

a. Researchers made the assumption that Miller syndrome is a recessive trait. Could Miller syndrome instead be due to a dominant mutation? If so, what scenarios would make this possible?
b. Why is it highly unlikely that Miller syndrome in this family is due to de novo mutations that occurred in the germ line of the mother, or of the father, or of both parents? Describe a scenario based on your understanding of cell divisions in human ovaries or testes (see Figs. 4.18 and 4.19) that make the de novo mutation hypothesis at least theoretically possible even if very unlikely
c. On Fig. 11.26b, indicate the location on chromosome 16 closest to the DHOD gene at which recombination took place during meiosis in one of the parents of the Miller syndrome patients. In which parent did this recombination occur?
d. Do the number of crossovers you see in Fig. 11.26b fit previous estimates that in the human genome, 1 centiMorgan corresponds to about 1 Mb? Chromosome 16 is about 90 Mb long; chromosome 17 is about 81 Mb long
e. How could researchers use all the sequence data from this family to estimate the per-nucleotide rate of mutation in humans?
Blurred answer
Students have asked these similar questions
unu grow because auxin is still produced in the tip to Another of Boysen and Jensen's experiments included the use of mica, explain why one of the shoots was able to show phototropism and the other was not. Mica Wafer Ligh c. They then t but this time permeable n shoot. Why phototropis Light Mica Wafer Coleoptile tips Tips removed: agar Explain why the shoo direction after the ag the cut shoot, even t
Discussion entries must be at least 250 words to fulfill the assignment requirements. You must complete your entry before you will be able to see the responses of other students. Responses to other students are encouraged but not required. Grading for discussion entries will be based on application of course concepts, proper grammar, and correct punctuation. Read one the attached article and explore the Human Development Index (https://hdr.undp.org/data-center/human-development-index#/indicies/HDI). In your opinion, is the Human Development Index a good measure of the well- being of the people of a nation? Are the items measured in the HDI valid and relevant in the modern global economy? How are they related to the political economy of a nation? The attached articles propose some alternative measures of well-being. In your opinion, are there other measures of well-being that might be better alternatives to the items in the current HDI?
A patient visits her doctor with symptoms typical of a bladder infection. She is immediately prescribed an 800 mgdose of antibiotic (bioavailability = 1/2, t½ = 12 h). The corresponding plasma concentration of drug is found to be 96 micrograms/ml. What is the volume of distribution of this drug? Please round to the nearest liter.

Chapter 11 Solutions

EBK GENETICS: FROM GENES TO GENOMES

Ch. 11 - Prob. 11PCh. 11 - The previous problem raises several interesting...Ch. 11 - You want to make a recombinant DNA in which a PCR...Ch. 11 - You sequence a PCR product amplified from a...Ch. 11 - Prob. 15PCh. 11 - The trinucleotide repeat region of the Huntington...Ch. 11 - Sperm samples were taken from two men just...Ch. 11 - Prob. 18PCh. 11 - a. It is possible to perform DNA fingerprinting...Ch. 11 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 11 - The figure that follows shows DNA fingerprint...Ch. 11 - Microarrays were used to determine the genotypes...Ch. 11 - A partial sequence of the wild-type HbA allele is...Ch. 11 - a. In Fig. 11.17b, PCR is performed to amplify...Ch. 11 - The following figure shows a partial microarray...Ch. 11 - Scientists were surprised to discover recently...Ch. 11 - The microarray shown in Problem 25 analyzes...Ch. 11 - The figure that follows shows the pedigree of a...Ch. 11 - One of the difficulties faced by human geneticists...Ch. 11 - Now consider a mating between consanguineous...Ch. 11 - The pedigree shown in Fig. 11.22 was crucial to...Ch. 11 - You have identified a SNP marker that in one large...Ch. 11 - The pedigrees indicated here were obtained with...Ch. 11 - Approximately 3 of the population carries a mutant...Ch. 11 - The drug ivacaftor has recently been developed to...Ch. 11 - In the high-throughput DNA sequencing protocol...Ch. 11 - A researcher sequences the whole exome of a...Ch. 11 - As explained in the text, the cause of many...Ch. 11 - Figure 11.26 portrayed the analysis of Miller...Ch. 11 - A research paper published in the summer of 2012...Ch. 11 - Table 11.2 and Fig. 11.27 together portray the...Ch. 11 - The human RefSeq of the entire first exon of a...Ch. 11 - Mutations in the HPRT1 gene in humans result in at...Ch. 11 - Prob. 44P
Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Text book image
Biology Today and Tomorrow without Physiology (Mi...
Biology
ISBN:9781305117396
Author:Cecie Starr, Christine Evers, Lisa Starr
Publisher:Cengage Learning
Text book image
Case Studies In Health Information Management
Biology
ISBN:9781337676908
Author:SCHNERING
Publisher:Cengage
Text book image
BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)
Biology
ISBN:9781305967359
Author:STARR
Publisher:CENGAGE L
Text book image
Human Biology (MindTap Course List)
Biology
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cengage Learning
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY