EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
expand_more
expand_more
format_list_bulleted
Question
Chapter 11, Problem 44P
Summary Introduction
To determine:
The difficulty in pinpointing genetic diseases and human cloning due to human mosacism.
Introduction:
The genes are the sequence of
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
A female child's parents are first cousins whose fathers are brothers. Each of the first cousins' fathers has a rare genetic disease
(that is 100% penetrant) and the child of the first cousins appears to have it also. The genomes of the child, the first cousins, and
their fathers have been sequenced and you're analyzing these genome sequences to identify the disease gene. Which of the
following should you expect?
Check All That Apply
Only the autosomes should be analyzed.
Both affected brothers and the affected child could be compound heterozygotes for two different rare mutations
in the same gene that affect gene function.
Both affected brothers and the affected child could be homozygous for the same rare mutation that affects the
function of a gene.
The two first cousins could both be heterozygous for the same rare mutation also found in the affected
individuals.
The two first cousins could each be heterozygous for different rare mutations, and their child should be a
compound…
Any permanent change to the structure of DNA is considered a mutation. A somatic cell mutation affects only the individual organism, while a germline mutation is passed onto the next generation.
For example, excessive amount of exposure to UV rays can lead to skin cancer. Although this type of mutation occurs in the somatic cells, every individual has different susceptibility to skin cell mutations upon exposure to UV rays.
The susceptibility is located in the germ cell and is heritable. The individuals who choose to overexpose themselves to UV rays increase their likelihood of obtaining undesirable mutations in their somatic cells.
Unlike suntanning, there are other activities we engage in that can lead to germline mutations. These activities should be avoided if possible as they lead to heritable mutations and cancer.
Using 200 words or less, identify one human activity that can lead to a heritable mutation.
Explain how it affects the individual and how it can be passed onto the…
All the cells of one organism share the same genome. However, during development, some cells develop into skin cells while others develop into muscle cells. Briefly explain how the same genetic instructions can result in two different cell types in the same organism.
Chapter 11 Solutions
EBK GENETICS: FROM GENES TO GENOMES
Ch. 11 - Choose the phrase from the right column that best...Ch. 11 - Would you characterize the pattern of inheritance...Ch. 11 - Would you be more likely to find single nucleotide...Ch. 11 - A recent estimate of the rate of base...Ch. 11 - If you examine Fig. 11.5 closely, you will note...Ch. 11 - Approximately 50 million SNPs have thus far been...Ch. 11 - Mutations at simple sequence repeat SSR loci occur...Ch. 11 - Humans and gorillas last shared a common ancestor...Ch. 11 - In 2015, an international team of scientists...Ch. 11 - Using PCR, you want to amplify an approximately 1...
Ch. 11 - Prob. 11PCh. 11 - The previous problem raises several interesting...Ch. 11 - You want to make a recombinant DNA in which a PCR...Ch. 11 - You sequence a PCR product amplified from a...Ch. 11 - Prob. 15PCh. 11 - The trinucleotide repeat region of the Huntington...Ch. 11 - Sperm samples were taken from two men just...Ch. 11 - Prob. 18PCh. 11 - a. It is possible to perform DNA fingerprinting...Ch. 11 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 11 - The figure that follows shows DNA fingerprint...Ch. 11 - Microarrays were used to determine the genotypes...Ch. 11 - A partial sequence of the wild-type HbA allele is...Ch. 11 - a. In Fig. 11.17b, PCR is performed to amplify...Ch. 11 - The following figure shows a partial microarray...Ch. 11 - Scientists were surprised to discover recently...Ch. 11 - The microarray shown in Problem 25 analyzes...Ch. 11 - The figure that follows shows the pedigree of a...Ch. 11 - One of the difficulties faced by human geneticists...Ch. 11 - Now consider a mating between consanguineous...Ch. 11 - The pedigree shown in Fig. 11.22 was crucial to...Ch. 11 - You have identified a SNP marker that in one large...Ch. 11 - The pedigrees indicated here were obtained with...Ch. 11 - Approximately 3 of the population carries a mutant...Ch. 11 - The drug ivacaftor has recently been developed to...Ch. 11 - In the high-throughput DNA sequencing protocol...Ch. 11 - A researcher sequences the whole exome of a...Ch. 11 - As explained in the text, the cause of many...Ch. 11 - Figure 11.26 portrayed the analysis of Miller...Ch. 11 - A research paper published in the summer of 2012...Ch. 11 - Table 11.2 and Fig. 11.27 together portray the...Ch. 11 - The human RefSeq of the entire first exon of a...Ch. 11 - Mutations in the HPRT1 gene in humans result in at...Ch. 11 - Prob. 44P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- DNA contains the genetic information that controls all processes of heredity in a cell. The total length of all DNA in the cells of a human body can stretch to the moon and back four times.The terms that describe a length of DNA and the form in which it remains for most of its life, respectively are: Select one: a. Length of DNA Form in which it spends most of its time life Centromere Locus b. Length of DNA Form in which it spends most of its time life Chromosome Chromatin c. Length of DNA Form in which it spends most of its time life Chromosome Centromere d. Length of DNA Form in which it spends most of its time life Centromere Telomerearrow_forwardWhen the human genome sequence was finally completed, scientists were surprised to discover that the genome contains far fewer genes than expected. How many genes are present in the human genome? Scientists have also found that there are many more different kinds of proteins in human cells than there are different genes in the genome. How can this be explained?arrow_forwardIt is possible to take the DNA of a gene from any source and place it on a chromosome in the nucleus of a yeast cell. When you take DNA of a human gene and put it into a yeast cell chromosome, the yeast cell can synthesize the human protein. However, when you remove the DNA for a gene normally present on yeast mitochondrial chromosomes and put it on a yeast chromosome in the nucleus, the yeast cell cannot synthesize the correct protein, even though the gene comes from the same organism. Explain. What would you need to do to ensure that such a yeast cell could make the correct protein?arrow_forward
- Please consider the figure below, parts A and B. A В Gene B Gene C Gene B Normal Gene A Chromosome 12 Normal Chromosome 1 Please consider figure A. a. Do these chromosomes come from a dividing or non-dividing cell? Give a reason for your answer. b. How many molecules of double stranded DNA will be present at anaphase I of a cell from this organism? Please consider figure B. A potentially carcinogenic mutation occurred on one of the chromosomes. The gene affected by the mutation codes for a protein involved in the repair of DNA damage. c. What is the correct term used to describe this chromosomal mutation? d. In terms of the development of cancer, is this a dominant or recessive mutation? e. What is the consequence of this mutation if it occurs during meiosis and is inherited by the offspring? Explain your answer in terms of the function of the protein.arrow_forwardMost forms of cancer are caused by environmental agents that produce mutations in somatic cells. Is an individual with cancer considered a genetic mosaic? Explain why or why not.arrow_forwardYour friend sends you two cancerous cell lines to examine and determine possible mutations. The results are shown below: Cell Line Mutation WT none (wild type DNA) 1 a deletion at the same region on both copies of chromosome 4 2 a point mutation in a gene on only one copy of chromosome 7 You learn that cell line 1 is a skin cancer cell line, and the deleted region normally contains an important cell cycle control gene. You obtain another cell line (cell line 3) that has one wild-type copy, and one loss-of-function mutant copy of this gene Based on this data, which of the following is true of the cell lines? Select all that apply Cell line 3 will display a cancerous phenotype The important cell cycle control gene could be p16, whose gene product prevents progression through the cell cycle unless all checks out Cell line 3 will display a normal phenotype V The important cell cycle control gene could be cyclin d, whose gene product drives G1 to S phase transitionarrow_forward
- Supergenes” are groups of genes located together inside chromosomal inversion. Supergenes seem to evolve together. Why does recombination not break up these coadaptive combinations of supergenes? ( be specific)arrow_forwardThis diagram shows a parental cell going through mitosis and producing 2 daughter cells. Which cells in th- mutation.) D |G H) D and G are genetically identical, but H is genetically different. O D and H are genetically identical, but G is genetically different. O Gand H are genetically identical, but D is genetically different. O All of the cells - D, G, and H - are genetically identical. O None of the cells in the diagram are genetically identical. All the cells - D, G, and H- are genetically different from each otlarrow_forwardAn STR on chromosome 5 is very closely linked to a gene involved in a dominant metabolism disorder (one one copy of the mutation causes the disease). There are four different alleles of the STR (Q, B, S, and L), each with different numbers of GATCTCG repeats. The S allele has 2 repeats, the B allele has 7 repeats, the Q allele has 10 repeats, and the L allele has 5 repeats. Part 1 Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the top of the gel. Move the letter of each allele to its correct position at the left of Lane 1 to indicate where each allele runs on the gel. 0000 Gabriel Andre Lane 1 O Maria Andre Maria Juliana B L Part 2 Andre and Maria are the parents in this family; all others shown on the gel are children. Daughter Juliana is born with the metabolism disorder, but daughter Camila does not have the disorder. Assuming no recombination between the STR…arrow_forward
- #15 & #16arrow_forwardA girl and a boy were born to a young married couple. The girl is absolutely healthy. The examination of the boy's karyotype has shown 46 chromosomes. But one of the chromosomes of the 15th pair is longer than normal as a part of a chromosome from the 21st pair has joined it. How many autosomes and sex chromosomes are in the boy's karyotype? Name the type of the mutation. Is it possible to consider this pathology an inherited disorder?arrow_forwardAccording to the endosymbiosis theory, mitochondria and chloroplasts are derived from bacteria that took up residence withineukaryotic cells. At one time, prior to being taken up by eukaryoticcells, these bacteria were free-living organisms. However, we cannot take a mitochondrion or chloroplast out of a living eukaryoticcell and get it to survive and replicate on its own. Discuss why not.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage LearningBiology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
What are Mutations and what are the different types of Mutations?; Author: Science ABC;https://www.youtube.com/watch?v=I16YlE8qTBU;License: Standard youtube license