EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
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Chapter 11, Problem 28P
The figure that follows shows the pedigree of a family in which a completely penetrant, autosomal dominant disease is transmitted through three generations, together with microarray analysis of each individual for a biallelic SNP locus (the alleles are C and T).
| a. | Do the data suggest the existence of genetic linkage between the SNP locus and the disease locus? If so, what is the estimated genetic distance between the two loci? |
| b. | Calculate the maximum Lod score for linkage between the SNP and the disease locus for this pedigree. What does this value of the Lod score signify? |
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FLORES DIology Second Semester Review
7. Chi Square Analysis: wild dumpy male x ebony wild female
F1:
All wild wild
F2:
142 wild wild males
52 wild ebony males
46 dumpy wild males
17 dumpy ebony males
151 wild wild females
47 wild ebony females
51 dumpy wild females
8 dumpy ebony females
What pattern of inheritance is observed for body color?
Autosomal recessive
Autosomal dominant
Sex-linked recessive
Sex-linked dominant
What are the genotypes of the parents in the P generation?
a.
XBYdd x XbXbDD
b. Bbdd x bbDd
c. BBdd x bbDD
d. BBX Y x bbXDY
How many flies in the F2 generation would you expect to express the dumpy wild phenotype?
a.
289.125
b. 97
c. 96.375
d. 293
4. This question focuses on entrainment.
a. What is entrainment?
b. What environmental cues are involved in entrainment, and which one is most influential?
c. Why is entrainment necessary?
d. Assuming that a flash of darkness is an effective zeitgeber, what impact on circadian
rhythms would you expect to result from an event such as the 2024 solar eclipse (assume
it was viewed from Carbondale IL, where totality occurred at about 2 pm)? Explain your
reasoning. You may wish to consult this phase response diagram.
Phase Shift (Hours)
Delay Zone
Advance Zone
Dawn
Mid-day
Dusk
Night
Dawn
Time of Light Stimulus
e. Finally, give a real-world example of how knowledge of circadian rhythms and
entrainment has implications for human health and wellbeing or conservation biology.
This example could be from your reading or from things discussed in class.
Generate one question that requires a Punnet Squre to solve the question. Then show how you calculate the possibilities of genotype and phenotype
Chapter 11 Solutions
EBK GENETICS: FROM GENES TO GENOMES
Ch. 11 - Choose the phrase from the right column that best...Ch. 11 - Would you characterize the pattern of inheritance...Ch. 11 - Would you be more likely to find single nucleotide...Ch. 11 - A recent estimate of the rate of base...Ch. 11 - If you examine Fig. 11.5 closely, you will note...Ch. 11 - Approximately 50 million SNPs have thus far been...Ch. 11 - Mutations at simple sequence repeat SSR loci occur...Ch. 11 - Humans and gorillas last shared a common ancestor...Ch. 11 - In 2015, an international team of scientists...Ch. 11 - Using PCR, you want to amplify an approximately 1...
Ch. 11 - Prob. 11PCh. 11 - The previous problem raises several interesting...Ch. 11 - You want to make a recombinant DNA in which a PCR...Ch. 11 - You sequence a PCR product amplified from a...Ch. 11 - Prob. 15PCh. 11 - The trinucleotide repeat region of the Huntington...Ch. 11 - Sperm samples were taken from two men just...Ch. 11 - Prob. 18PCh. 11 - a. It is possible to perform DNA fingerprinting...Ch. 11 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 11 - The figure that follows shows DNA fingerprint...Ch. 11 - Microarrays were used to determine the genotypes...Ch. 11 - A partial sequence of the wild-type HbA allele is...Ch. 11 - a. In Fig. 11.17b, PCR is performed to amplify...Ch. 11 - The following figure shows a partial microarray...Ch. 11 - Scientists were surprised to discover recently...Ch. 11 - The microarray shown in Problem 25 analyzes...Ch. 11 - The figure that follows shows the pedigree of a...Ch. 11 - One of the difficulties faced by human geneticists...Ch. 11 - Now consider a mating between consanguineous...Ch. 11 - The pedigree shown in Fig. 11.22 was crucial to...Ch. 11 - You have identified a SNP marker that in one large...Ch. 11 - The pedigrees indicated here were obtained with...Ch. 11 - Approximately 3 of the population carries a mutant...Ch. 11 - The drug ivacaftor has recently been developed to...Ch. 11 - In the high-throughput DNA sequencing protocol...Ch. 11 - A researcher sequences the whole exome of a...Ch. 11 - As explained in the text, the cause of many...Ch. 11 - Figure 11.26 portrayed the analysis of Miller...Ch. 11 - A research paper published in the summer of 2012...Ch. 11 - Table 11.2 and Fig. 11.27 together portray the...Ch. 11 - The human RefSeq of the entire first exon of a...Ch. 11 - Mutations in the HPRT1 gene in humans result in at...Ch. 11 - Prob. 44P
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