Chapter 11, Problem 2P

Interpretation Introduction

(a) Interpretation:

Determination of whether the following intracellular concetration ratio will be 1, >1, or <1: a. [NAD⁺]/ [NADH].

Concept introduction:

The major electron donors required for reductive biosynthesis is nicotinamide adenine dinucleotide phosphate (NADPH). NADPH and NADP+ are similar to NADH and NAD+ respectively. The nicotinamide nucleotide-linked enzymes which act in catabolic direction use NAD⁺/ NADH, whereas those which act in anabolic reactions uses NADP⁺/NADPH.

Interpretation Introduction

(b) Interpretation:

Determination of whether the following intracellular concetration ratio will be 1, >1, or <1: b. [NADP⁺/[NADPH].

Concept introduction:

The major electron donors required for reductive biosynthesis is nicotinamide adenine dinucleotide phosphate (NADPH). NADPH and NADP+ are similar to NADH and NAD+ respectively. The nicotinamide nucleotide-linked enzymes which act in catabolic direction use NAD⁺/ NADH, whereas those which act in anabolic reactions uses NADP⁺/NADPH.

Interpretation Introduction

(c) Interpretation:

Determination of the process by which the concentration ratios might be maintained inside cells at greatly differing values since NAD+ and NADP+ are essentially equivalent in their tendency to attract electrons.

Concept introduction:

The major electron donors required for reductive biosynthesis is nicotinamide adenine dinucleotide phosphate (NADPH). NADPH and NADP+ are similar to NADH and NAD+ respectively. The nicotinamide nucleotide-linked enzymes which act in catabolic direction use NAD⁺/ NADH, whereas those which act in anabolic reactions uses NADP⁺/NADPH.