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Curren'S Math For Meds: Dosages & Sol

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter10: Reconstitution Of Powdered Drugs

Section: Chapter Questions

Problem 44SST

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Where would 14C have to be in the starting glucose to ensure that the fermentation process releases all of the 14C label
as 14 CO2?
The 14C label could be in the C-1 position of glucose.
The 14C label could be in the C-2 position of glucose.
The 14C label could be in the C-3 position of glucose.
The 14C label could be in the C-4 position of glucose.
14C label could be in the C-5 position of glucose.
The
The 14C label could be in the C-6 position of glucose.

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A “pulse-chase” experiment using 14C-labeled carbon sources is carried out on a yeast extract maintained under strictly anaerobic conditions to produce ethanol. The experiment consists of incubating a small amount of14C-labeled substrate (the pulse) with the yeast extract just long enough for each intermediate in the fermentation pathway to become labeled. The label is then “chased” through the pathway by the addition of excess unlabeled glucose. The chase effectively prevents any further entry of labeled glucose into the pathway.(a) If [1-14C]glucose (glucose labeled at C-1 with 14C) is used as a substrate, what is the location of 14C in the product ethanol? Explain.(b) Where would 14C have to be located in the starting glucose to ensure that all the 14C activity is liberated as 14CO2 during fermentation to ethanol? Explain.
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As you know Penicillin is produced biosynthetically from cysteine and valine. If thebiosynthetic pathway could accept different amino acids, why do you think penicillin analogsare not formed during the fermentation process, with different amino acids is used?
Two groups of tomatoes were grown under laboratoryconditions, one with humus added to the soil and one acontrol without humus. The leaves of the plants grownwithout humus were yellowish (less green) compared withthose of the plants grown in humus-enriched soil. The bestexplanation is that(A) the healthy plants used the food in the decomposing leavesof the humus for energy to make chlorophyll.(B) the humus made the soil more loosely packed, so waterpenetrated more easily to the roots.(C) the humus contained minerals such as magnesium andiron needed for the synthesis of chlorophyll.(D) the heat released by the decomposing leaves of the humuscaused more rapid growth and chlorophyll synthesis.
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