(Biochemistry topics: Glycolysis, Citric Acid Cycle, and Electron Transport.)  There is a reciprocal regulation of glycolytic and gluconeogenic reactions interconverting fructose-6-phosphate and fructose-1,6-biphosphate. Which one of the following statements about this regulation is not correct? This regulation allows control of the direction of net metabolite flow through the pathway. Fructose-2,6- bisphosphate activates phosphofructokinase-1. Fructose-2,6-biphosphate inhibits fructose-1,6-bisphosphate. The fructose-1,6-bisphosphatase reaction is exergonic.  The PFK1 reaction is exergonic.

Biochemistry
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Chapter19: The Tricarboxylic Acid Cycle
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(Biochemistry topics: Glycolysis, Citric Acid Cycle, and Electron Transport.) 

There is a reciprocal regulation of glycolytic and gluconeogenic reactions interconverting fructose-6-phosphate and fructose-1,6-biphosphate. Which one of the following statements about this regulation is not correct?

  • This regulation allows control of the direction of net metabolite flow through the pathway.
  • Fructose-2,6- bisphosphate activates phosphofructokinase-1.
  • Fructose-2,6-biphosphate inhibits fructose-1,6-bisphosphate.
  • The fructose-1,6-bisphosphatase reaction is exergonic. 
  • The PFK1 reaction is exergonic. 
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