Which of the following statements is false concerning the ‘tight binding site’ of ATP Synthase within the natural environment of the mitochondria? Group of answer choices ATP is released from the tight binding site This is a binding site found within an αβ subunits of the F1 portion of ATP Synthase The tight binding forces the reaction of ADP + Pi → ATP The tight binding site has the lowest KM for ATP

Which of the following statements is false concerning the ‘tight binding site’ of ATP Synthase within the natural environment of the mitochondria? Group of answer choices ATP is released from the tight binding site This is a binding site found within an αβ subunits of the F1 portion of ATP Synthase The tight binding forces the reaction of ADP + Pi → ATP The tight binding site has the lowest KM for ATP

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter27: Metabolic Integration And Organ Specialization

Section: Chapter Questions

Problem 20P: Figure 27.3 illustrates the response of R (ATP-regenerating) and U (ATP-utilizing) enzymes to energy...

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Which of the following statements best explains why the activity of ATP-citrate lyase and malic enzyme are often paired together? The use of ATP by ATP-citrate lyase means that NADH needs to be regenerated cytosolically so that more ATP can be generated via shuttle systems and replace the ATP used by ATP-citrate lyase ATP-citrate lyase produces ATP and malic enzyme produces NADPH, both needed in the fatty acid biosynthetic pathway The activity of ATP-citrate lyase and malic enzyme never are correlated, they always function in different realms of metabolism The generation of acetyl CoA is a substrate for fatty acid synthesis in the cytosol and NADPH is generated as the anabolic electron carrier
Which is the correct link between conformation of the beta-subunit of the F1 component of the ATP synthase and ADP+P¡ or ATP? loose Binding Change Mechanism binding ATP ADP+P ATP Crepeat ADP ADP +P; ATP ATP +P; tight binding open ATP loose => binding ADP+Pi open => catalyzes ADP+P¡ into ATP tight => releases ATP open => releases ADP+P¡
Describe the conformational changes (including substrates that bind to the different conformations) that occur in the F1 domain of ATP Synthase that result from protons flowing through the Fo domain down their concentration gradient:
Which of the following regarding the ATP Synthase is INCORRECT? Protons flow through the a and c subunits The translocation of four protons through the ATP synthase fuels the synthesis of one ATP molecule The F1 domain can function as an ATPase The y subunit rotates while the xß dimers are stationary
V-class proton pumps run backward relative to the F-class ATP synthase. Consider the cartoon, which shows the conformations of the beta-subunits and ATPIADP + Pj of the F-class synthase. Which of the following associations between the conformation of the beta subunit and ATP/ADP + P¡ is correct for V- Binding Change Mechanism loose binding ADP+P ATP ATP class pumps? C repeat ADP + P, ADP АТР tight binding АТР +P оpen АТР O The open conformation releases ATP. Hydrolysis of ATP to ADP + P¡ drives the change from tight to loose. O Binding of ADP + P¡ drives change from open to loose. Hydrolysis of ATP to ADP + Pj drives the change from open to loose.
The AG of the reaction C6H12O6 + 60₂ --> 6CO₂ + 6H₂O is -686 kcal/mol glucose oxidized. The AG of the reaction ADP + P₁ --> ATP + H₂O is + 7.3 kcal/mol ATP synthesized. The oxidation of glucose can be coupled to the synthesis of ATP. If the coupling is 50% efficient, how many molecules of ATP can be synthesized per molecule of glucose oxidized? Round your answer to the nearest whole number.
A poison that prevents the transfer of electrons from the last [Fe-S] cluster of Complex I to coenzyme Q is added to a suspension of actively respiring mitochondria. Which of the following will be observed? ATP production would be impaired due to the uncoupling of oxidative phosphorylation from electron transport. ATP production would be reduced due to inhibition of the CoQ subunit of ATP synthase. ATP production would be reduced due to a decrease in the number of protons pumped out of the mitochondrial matrix. ATP production would be halted completely due to the block in electron transport through the electron transport chain.
b) Place a 'Yes' or a 'No' in the appropriate boxes that correspond to each listed feature of cellular respiration. You may need to state 'Yes' or 'No' in more than one box in a particular row in some cases. Cellular Respiration Feature Involved in aerobic respiration Occurs in the mitochondrial matrix Pyruvate molecules are produced Acetyl COA combines with a 4 carbon molecule Electrons are passed between protein carriers ATP is produced NAD+ gains hydrogen FADH₂ loses hydrogen Glycolysis Yes / No Krebs Cycle Yes / No Electron Transport chain Yes / No
b) Place a 'Yes' or a 'No' in the appropriate boxes that correspond to each listed feature of cellular respiration. You may need to state 'Yes' or 'No' in more than one box in a particular row in some cases. Cellular Respiration Feature Involved in aerobic respiration Occurs in the mitochondrial matrix Pyruvate molecules are produced Acetyl CoA combines with a 4 carbon molecule Electrons are passed between protein carriers ATP is produced NAD* gains hydrogen FADH₂ loses hydrogen Glycolysis Yes / No Krebs Cycle Yes / No Electron Transport chain Yes/No 90+
The AG of the reaction C6H1206+602 --> 6 CO2 + 6H₂O is -686 kcal/mol glucose oxidized. The AG of the reaction ADP + P --> ATP + H₂O is + 7.3 kcal/mol ATP synthesized. The oxidation of glucose can be coupled to the synthesis of ATP. If the coupling is 50% efficient, how many molecules of ATP can be synthesized per molecule of glucose oxidized? Round your answer to the nearest whole number. Type your answer... rces K esc Q 7 c с 72 W #3 E 14 R LL Search or type URL % 65 T G A MacBook Pro 6 Y H & 7 U * 8 + - ( 9 J ၂ ။ K 0 ) 0 L P { + 11 } ] Submit delete return
Oxidative phosphorylation generates ATP using the reducing power of [NADH, FADH2 or malate] to move electrons down a series of carriers to ultimately produce a [phosphate gradient or protons gradient] across the inner mitochondrial membrane, which is used by ATP synthase to make ATP. ATP synthase harnesses the energy stored in both [charge and concentration gradients or electostatic and van der waals interations] to achieve high energy phosphate bond synthesis. If the ion gradient across the inner membrane is dissipated by the expression of UCP1, ATP is not synthesized and [heat is generated or electron transport is blocked]. The final electron acceptor in the electron transport chain is [oxygen or carbon dioxide] with water as a product.
During chemiosmosis ATP is synthesized when H + ions move through turnstile like channel of ATP synthase. H+ ions serve as the final electron acceptor. energy is released as H+ ions move freely across mitochondrial membranes. a concentration gradient is generated when large numbers of H+ ions are passively transported from the matrix of the mitochondrion to the mitochondrion's intermembrane space. 2.86 points Save Answer