each c) Abe is 80 years old with no history of heart problems but is currently taking drugs to manage his diabetes and diabetic nephropathy (kidney disease). He presented with high blood pressure and was treated with calcium channel blockers but was admitted to hospital feeling light-headed and lethargic. Туре Modifying Factor PK-Intrinsic PD - Exstrinsic Your example Mechanisms / affected process Effect on outcome d) Jim is a 34 year old amateur triathlete with a clean bill of health. He works at the local explosives factory and presents at the clinic with an irregular heartbeat (arrhythmia). Jim is prescribed a standard dose of potassium channel blockers but his arrhythmia persisted. Type Modifying Factor Your example PK - Extrinsic Mechanisms / affected process Effect on outcome PD - Instrinsic VII. You are charged with reviewing clinical case reports to identify modifying factors that may have contributed to therapeutic failure (lack of response) and toxic side effects experience by patients. For each case report, identify two potential modifying factors as indicated in the left column, as well as the affected process or mechanism, and the related impact on patient outcome. For the eight modifying factors you identify (4 cases x 2 factors, 8 points): • Credit will only be given once for repeated answers (same factor influencing the same process) • PK = pharmacokinetic; PD=pharmacodynamic a) Petunia is 19-years old and weighs 103 lbs. She is generally in good health and credits this to a vegetarian diet and regular use of herbal tea. She was diagnosed with a pulmonary infection and was prescribed an oral antibiotic that did not work and required additional treatment. Type example: Mechanisms / affected process Effect on outcome Modifying Factor Your example Pharmacokinetic high fibre diet faster transit time in the digestive tract - reduced absorption lack of therapeutic effect due to reduced bioavailability PK-Exstrinsic PD-Instrinsic b) Charlie is a 52-year old female alcoholic who has been depressed for years but does not respond to treatment with typical antidepressants. Trying a new approach, Charlie is prescribed a GABA receptor agonist but experiences severe fatigue and respiratory depression. Type Modifying Factor Your example PK - Intrinsic Mechanisms / affected process Effect on outcome PD - Exstrinsic

each c) Abe is 80 years old with no history of heart problems but is currently taking drugs to manage his diabetes and diabetic nephropathy (kidney disease). He presented with high blood pressure and was treated with calcium channel blockers but was admitted to hospital feeling light-headed and lethargic. Туре Modifying Factor PK-Intrinsic PD - Exstrinsic Your example Mechanisms / affected process Effect on outcome d) Jim is a 34 year old amateur triathlete with a clean bill of health. He works at the local explosives factory and presents at the clinic with an irregular heartbeat (arrhythmia). Jim is prescribed a standard dose of potassium channel blockers but his arrhythmia persisted. Type Modifying Factor Your example PK - Extrinsic Mechanisms / affected process Effect on outcome PD - Instrinsic VII. You are charged with reviewing clinical case reports to identify modifying factors that may have contributed to therapeutic failure (lack of response) and toxic side effects experience by patients. For each case report, identify two potential modifying factors as indicated in the left column, as well as the affected process or mechanism, and the related impact on patient outcome. For the eight modifying factors you identify (4 cases x 2 factors, 8 points): • Credit will only be given once for repeated answers (same factor influencing the same process) • PK = pharmacokinetic; PD=pharmacodynamic a) Petunia is 19-years old and weighs 103 lbs. She is generally in good health and credits this to a vegetarian diet and regular use of herbal tea. She was diagnosed with a pulmonary infection and was prescribed an oral antibiotic that did not work and required additional treatment. Type example: Mechanisms / affected process Effect on outcome Modifying Factor Your example Pharmacokinetic high fibre diet faster transit time in the digestive tract - reduced absorption lack of therapeutic effect due to reduced bioavailability PK-Exstrinsic PD-Instrinsic b) Charlie is a 52-year old female alcoholic who has been depressed for years but does not respond to treatment with typical antidepressants. Trying a new approach, Charlie is prescribed a GABA receptor agonist but experiences severe fatigue and respiratory depression. Type Modifying Factor Your example PK - Intrinsic Mechanisms / affected process Effect on outcome PD - Exstrinsic

Comprehensive Medical Terminology

4th Edition

ISBN:9781133478850

Author:Jones

Publisher:Jones

Chapter22: Pharmacology

Section: Chapter Questions

Problem I9CRE

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