Answered: This UCP1 protein allows the protons…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question

This UCP1 protein allows the protons (H⁺) of the mitochondrial intermembrane space to enter the mitochondrial matrix without going through the ATP synthase. This bypass represents a shortcut for protons and uncouples (i.e. eliminates the interrelationship between) the following two processes:

The entry of protons inside the mitochondrial matrix, following their concentration gradient.
The phosphorylation of ADP into ATP by the ATP synthase.

It is this uncoupling that gave the protein its name: uncoupling protein 1 (UCP1).

The following figure shows the location of UCP1 when it is expressed (synthesized) in the brown adipose tissues (BAT) of hibernating mammals.

Question 12

Based on the UCP1 protein structure shown earlier, and based on the figure above, what type of protein is UCP1?

Question 12 options:

a)	A primary active transporter.

b)	A motor protein.

c)	A secondary active transporter.

d)	A passive transporter.

e)	A coenzyme.

Cytoplasm
Outer
menda
Intermembrane
In
netrare
Mitochondrial
4H
CoQ
NADH NAD Succinate
2H
4H*
Fumarate
+2H²
Cyt
2H'
[2H+1/20, 20
H₂0x2]
ATP
synthase
ADP
ATP
UCP1

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