Consider a liver cell carrying out the oxidation of glucose and fatty acids under aerobic conditions. Then, a very potent and specific inhibitor of the mitochondrial ATP synthase is added, completely inhibiting this enzyme. What will happen to the rate of the citric acid cycle? O No change in the rate of the citric acid cycle O Increased due to the demand for reduced electron carriers to power reactions instead of ATP O Increased due to an accumulation of protons in the mitochondrial intermembrane space O Reduced due to the accumulation of the products of the cycle that act as feedback inhibitors O Reduced as some enzymes of the cycle share the same active site as ATP synthase and will therefore be inhibited
Consider a liver cell carrying out the oxidation of glucose and fatty acids under aerobic conditions. Then, a very potent and specific inhibitor of the mitochondrial ATP synthase is added, completely inhibiting this enzyme. What will happen to the rate of the citric acid cycle? O No change in the rate of the citric acid cycle O Increased due to the demand for reduced electron carriers to power reactions instead of ATP O Increased due to an accumulation of protons in the mitochondrial intermembrane space O Reduced due to the accumulation of the products of the cycle that act as feedback inhibitors O Reduced as some enzymes of the cycle share the same active site as ATP synthase and will therefore be inhibited
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:Consider a liver cell carrying out the oxidation of glucose and fatty acids under aerobic
conditions. Then, a very potent and specific inhibitor of the mitochondrial ATP
synthase is added, completely inhibiting this enzyme. What will happen to the rate of
the citric acid cycle?
No change in the rate of the citric acid cycle
O Increased due to the demand for reduced electron carriers to power reactions instead of ATP
O Increased due to an accumulation of protons in the mitochondrial intermembrane space
Reduced due to the accumulation of the products of the cycle that act as feedback inhibitors
O Reduced as some enzymes of the cycle share the same active site as ATP synthase and will
therefore be inhibited
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