Consider a liver cell carrying out the oxidation of glucose and fatty acids under aerobicconditions. Then, a very potent and specific inhibitor of the mitochondrial ATPsynthase is added, completely inhibiting this enzyme. What will happen to the rate ofthe citric acid cycle?No change in the rate of the citric acid cycleO Increased due to the demand for reduced electron carriers to power reactions instead of ATPO Increased due to an accumulation of protons in the mitochondrial intermembrane spaceReduced due to the accumulation of the products of the cycle that act as feedback inhibitorsO Reduced as some enzymes of the cycle share the same active site as ATP synthase and willtherefore be inhibited

ATP is the energy currency of the cell and is primarily produced by ATP synthase present in the…

Answered: Consider a liver cell carrying out the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Concerning the citric acid cycle (TCA cycle), which of the following statements is false? The TCA cycle generates electron carriers Oxidation of pyruvate in the matrix of the mitochondria produces sixteen total electrons Substrate level phosphorylation in the TCA cycle produces 2 GTP per the oxidation of a single glucose molecule The fate of the carbonyl carbon of acetyl CoAin the TCA cycle is to be lost as CO2 in the second turn Oxygen is required to regenerate electron acceptors
Which statement is not completely true? O Stage 3 is composed of the citric acid cycle, and the elecrtron transport chain coupled with oxidative phosphorylation. O Anabolism are reactions involved in the breakdown of biomolecules energy is released. O The ultimate goal of the 3 stages of catabolism is to regenerate ATP from ADP. O In Stage 2 of Catabolism, the main energy molecule that all macronutrients are broken down into is Acetyl groups (combined with the shuttle CoA) to form Acetyl COA. O An array of chemical reactions (series of steps) that are organized into orderly well regulated sequences are called metabolic pathways. O The purpose of the citric acid cycle is to regenerate NAD* and FAD to NADH and FADH2
NADH and succinate are substrates that can be oxidized and will consume oxygen. Rotenone and cyanide are inhibitors of the electron transport chain and can block oxidation. Match each description of the effector to the appropriate oxygen consumption. A plot may match more than one description. Some plots will not match any description. (At least one of the matches in the image was incorrect)
The primary role citric acid cycle is to collect high energy electrons from the oxidation of carbons in the form of NADH and FADH2. If the electron transport chain is inhibited, would you expect the citric acid cycle to be more active or lessactive? Explain your answer.
Cancer cells need more DNA synthesis but the NADPH/ NADP* ratio is high. Which of the following statement is TRUE? Flux through the oxidative reactions is low and the nonoxidative reactions are reversed in order to form ribose 5-phosphate. O b. The oxidative reactions and the isomerase supply both ribose 5-phosphate and NADPH with little flux through the nonoxidative branch. O C. Flux through the oxidative reactions increases and ribose 5-phosphate is shunted into glycolysis by the nonoxidative reactions. Od. The ribose 5-phosphate is recycled through the oxidative steps via the nonoxidative reactions and gluconeogenesis.
The proton-motive force is a measure of the potential energy generated across the mitochondrial inner membrane during electron transport. Explain the factors that constitute this potential energy, that will be converted to the chemical energy of ATP by the cell
During glycolysis, glucose is converted to pyruvate. Pyruvate then is converted to Acetyl coA and enters the citric acid cycle. Per one (1) glucose molecule that undergoes glycolysis and TCA cycle, complete the table below ATPS produced Products from glycolysis 1. ATP 2. NADH 3. _Pyruvate Equivalence in ATP ATP ATPS АТР Equivalence in ATP ATPS Products from TCA ATPS produced АТР 4. NADH 5. FADH2 6. GTP ATPS ATP ATPS ATP TOTAL ATP Produced 7. ATP
Tell how many ATPs result from from oxidative phosphorylation of one NADH; tell how many ATPs result from oxidation phosphorylation of one FADH2.
Suppose a liver cell developed a mutation such that all of its ATP synthase complexes are now super efficient, and they now only require 1 H+ to pass through the complex to produce one molecule of 1 ATP! How many net ATP would be produced in these liver cells from the complete oxidation of 1 molecule of glucose?
Match group A with group B: Group A Group B ATP synthase that makes ATP, is a Pyruvate part of Transfers the electrons from cyt c to O2 NADH Both glycogen synthesis and glycogen +NAD breakdown share the metabolite Glucose converted into two of these ТСА суcle molecules a-ketoglutarate dehydrogenase ETC inhibited by The central catabolic pathway is Ubiquinone Cytochrome c oxidase Glucose-1- phosphate
Which of the following is true for both aerobic and anaerobic cellular respiration? A B с D oxidation of FADH₂ to FAD reduction of FAD to FADH₂ oxidation of NADH to NAD + reduction of NAD * to NADH
If actively respiring mitochondria are exposed to an inhibitor of ATPADP translocase, the electrontransport chain ceases to operate. Why?

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