Normally, the flow of electrons to O2 is tightlylinked to the production of ATP via the electrochemicalgradient. If ATP synthase is inhibited, for example, elec-trons do not flow down the electron-transport chain andrespiration ceases. Since the 1940s, several substances—such as 2,4-dinitrophenol—have been known to uncou-ple electron flow from ATP synthesis. Dinitrophenol wasonce prescribed as a diet drug to aid in weight loss. Howwould an uncoupler of oxidative phosphorylation pro-mote weight loss? Why do you suppose dinitrophenol isno longer prescribed?
Normally, the flow of electrons to O2 is tightlylinked to the production of ATP via the electrochemicalgradient. If ATP synthase is inhibited, for example, elec-trons do not flow down the electron-transport chain andrespiration ceases. Since the 1940s, several substances—such as 2,4-dinitrophenol—have been known to uncou-ple electron flow from ATP synthesis. Dinitrophenol wasonce prescribed as a diet drug to aid in weight loss. Howwould an uncoupler of oxidative phosphorylation pro-mote weight loss? Why do you suppose dinitrophenol isno longer prescribed?
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter20: Electron Transport And Oxidative Phosphorylation
Section: Chapter Questions
Problem 11P
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Question
Normally, the flow of electrons to O2 is tightly
linked to the production of ATP via the
gradient. If ATP synthase is inhibited, for example, elec-
trons do not flow down the electron-transport chain and
respiration ceases. Since the 1940s, several substances—
such as 2,4-dinitrophenol—have been known to uncou-
ple electron flow from ATP synthesis. Dinitrophenol was
once prescribed as a diet drug to aid in weight loss. How
would an uncoupler of oxidative phosphorylation pro-
mote weight loss? Why do you suppose dinitrophenol is
no longer prescribed?
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