Normally, the flow of electrons to O2 is tightlylinked to the production of ATP via the electrochemicalgradient. If ATP synthase is inhibited, for example, elec-trons do not flow down the electron-transport chain andrespiration ceases. Since the 1940s, several substances—such as 2,4-dinitrophenol—have been known to uncou-ple electron flow from ATP synthesis. Dinitrophenol wasonce prescribed as a diet drug to aid in weight loss. Howwould an uncoupler of oxidative phosphorylation pro-mote weight loss? Why do you suppose dinitrophenol isno longer prescribed?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Normally, the flow of electrons to O2 is tightly
linked to the production of ATP via the electrochemical
gradient. If ATP synthase is inhibited, for example, elec-
trons do not flow down the electron-transport chain and
respiration ceases. Since the 1940s, several substances—
such as 2,4-dinitrophenol—have been known to uncou-
ple electron flow from ATP synthesis. Dinitrophenol was
once prescribed as a diet drug to aid in weight loss. How
would an uncoupler of oxidative phosphorylation pro-
mote weight loss? Why do you suppose dinitrophenol is
no longer prescribed?

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