The fatty acid side chains of the phospholipids in the inner mitochondrial membrane exhibit a large proportion of multiple unsaturations. As a result, will the membrane be hydrophobic or hydrophilic? Also will it be more fluid or more rigid? How do these characteristics help explain the observation that the inner membrane is impermeable to ions such as Mg2+ and Cl–? Hint: what moves these ions through the membrane?
The fatty acid side chains of the phospholipids in the inner mitochondrial membrane exhibit a large proportion of multiple unsaturations. As a result, will the membrane be hydrophobic or hydrophilic? Also will it be more fluid or more rigid? How do these characteristics help explain the observation that the inner membrane is impermeable to ions such as Mg2+ and Cl–? Hint: what moves these ions through the membrane?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
The fatty acid side chains of the phospholipids in the inner mitochondrial membrane exhibit a large proportion of multiple unsaturations. As a result, will the membrane be hydrophobic or hydrophilic? Also will it be more fluid or more rigid? How do these characteristics help explain the observation that the inner membrane is impermeable to ions such as Mg2+ and Cl–? Hint: what moves these ions through the membrane?
![Objective: Perform calculations about the free energy change and electric potential
across various membranes, illustrating differences between them.
1. Recall the membrane proton-transport free energy equation:
AG = 2.3 RT [pH(side 1) - pH (side 2)] + Z FAY
=
where Z = the charge on the proton (+1), F = Faraday's constant = 96485 C/mol and R
gas constant = 8.314 J/K mol.
For the inner membrane of a mitochondrion, AY = + 0.168 V; use T = 310K (37°C) and
pH(matrix) - pH (intermembrane space) = 0.75.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F0627210d-c0e3-4a2a-8541-a7399a2e5e96%2F33961fa4-d3f0-478a-b85f-b35535d83600%2Fj41xwbe_processed.png&w=3840&q=75)
Transcribed Image Text:Objective: Perform calculations about the free energy change and electric potential
across various membranes, illustrating differences between them.
1. Recall the membrane proton-transport free energy equation:
AG = 2.3 RT [pH(side 1) - pH (side 2)] + Z FAY
=
where Z = the charge on the proton (+1), F = Faraday's constant = 96485 C/mol and R
gas constant = 8.314 J/K mol.
For the inner membrane of a mitochondrion, AY = + 0.168 V; use T = 310K (37°C) and
pH(matrix) - pH (intermembrane space) = 0.75.
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