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Citrate synthase is a nuclear-encoded enzyme of the Citric Acid Cycle.  The enzyme is functional in the mitochondrial matrix.    Looking at the system required for mitochondrial targeting and import of citrate synthase, which of the following statements are correct?     1.  Proper import and processing of citrate synthase is dependent upon other proteins found in the mitochondria. 2.  Because of the signal peptide, the mature functional enzyme is actually longer than it would be if it was coded by the organelle genome. 3.  Because the citrate synthase signal peptide doesn’t have a precise amino acid signature, mutations that slightly change the primary sequence have no effect on targeting. 4.  To get citrate synthase into the mitochondrial matrix requires two signal sequences: one to get it across the outer membrane and a second to get it across the inner membrane.   A.  1,2 and 3   B.  1 and 3   C.  2 and 4   D.  4 only   E. All of 1,2,3 and 4 are correct

Citrate synthase is a nuclear-encoded enzyme of the Citric Acid Cycle.  The enzyme is functional in the mitochondrial matrix.    Looking at the system required for mitochondrial targeting and import of citrate synthase, which of the following statements are correct?     1.  Proper import and processing of citrate synthase is dependent upon other proteins found in the mitochondria. 2.  Because of the signal peptide, the mature functional enzyme is actually longer than it would be if it was coded by the organelle genome. 3.  Because the citrate synthase signal peptide doesn’t have a precise amino acid signature, mutations that slightly change the primary sequence have no effect on targeting. 4.  To get citrate synthase into the mitochondrial matrix requires two signal sequences: one to get it across the outer membrane and a second to get it across the inner membrane.   A.  1,2 and 3   B.  1 and 3   C.  2 and 4   D.  4 only   E. All of 1,2,3 and 4 are correct

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Citrate synthase is a nuclear-encoded enzyme of the Citric Acid Cycle.  The enzyme is functional in the mitochondrial matrix. 

 

Looking at the system required for mitochondrial targeting and import of citrate synthase, which of the following statements are correct?

 

 

1.  Proper import and processing of citrate synthase is dependent upon other proteins found in the mitochondria.

2.  Because of the signal peptide, the mature functional enzyme is actually longer than it would be if it was coded by the organelle genome.

3.  Because the citrate synthase signal peptide doesn’t have a precise amino acid signature, mutations that slightly change the primary sequence have no effect on targeting.

4.  To get citrate synthase into the mitochondrial matrix requires two signal sequences: one to get it across the outer membrane and a second to get it across the inner membrane.

  •  
    A. 

    1,2 and 3

  •  
    B. 

    1 and 3

  •  
    C. 

    2 and 4

  •  
    D. 

    4 only

  •  
    E. All of 1,2,3 and 4 are correct
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