What is the role of aconitase in the TCA? One of the functions of the cytosolic isozyme is similar to that of the mitochondrial isozyme. How is it similar and how is it different? What is the other function of the cytosolic isozyme of aconitase?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Most enzymes have a single function however there is a growing number of enzymes found to be “moonlighting” that is, doing more than one job in the cell. Aconitase is one of these enzymes. The mitochondrial isozyme is a component of the tricarboxylic acid cycle.  However there also is a cytosolic isozyme of aconitase.  Discuss the two roles of this cytosolic enzyme.

  1. What is the role of aconitase in the TCA?
  2. One of the functions of the cytosolic isozyme is similar to that of the mitochondrial isozyme. How is it similar and how is it different?
  3. What is the other function of the cytosolic isozyme of aconitase?
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