Phosphofructokinase (PFK) catalyzes a key step in glycolysis. This enzyme is composed of three distinct subunits, muscle (M), liver (L) and platelet (P), which are expressed in different tissues. Mature human muscle contains exclusively the M isoform, while red blood cells express both M & L subunits. PFK gene mutations lead to M protein deficiency, intolerance to vigorous exercise and may lead to hemolytic anemia (Tarui disease). Which of the following can you conclude from the above information? Select all that apply. O The muscle cells will be able to generate ATP through oxidative phosphorylation in the presence of oxygen UThere may be a total lack of PFK activity in muscle O The red blood cells will be able to generate ATP through oxidative phosphorylation in the presence of oxygen U Hemolytic anemia may be due to instability of the L subunits in red blood cells

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Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.