NGS sequencing made it easy to generate COVID-19 sequences and compare them at different time points. Using what you learn in the course you are able to analyze COVID-19 data at different waves. Requirements 1. Use the GISAID database (GISAID) to download COVID-19 sequences (at least ten samples) at different time points. 2. Perform multiple sequence alignment for your samples. 3. Generate a phylogenetic tree and visualize it. 4. Use BLAST to align COVID-19 spike protein with other viral spike proteins. 5. Choose the most homologous protein and annotate it using ensemble or any preferred database. 6. All analysis steps must be delivered in bash script

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Genetic Evolution

Sexual reproduction produces distinct population variations. Heredity determines the traits and qualities to be passed down to the progeny. Over time, this variation within-species is also affected by the process of human evolution. The study of how genetic variation leads to evolutionary changes is known as genetic evolution. If a trait helps an organism to survive and reproduce, it is more likely to be passed down the generations. It is rare that such traits result in a completely distinct set of traits in descendants than the ancestral population; this can result in the emergence of a new species.