In a particular country in sub-Saharan Africa, a medical study revealed that 0.075% of the country's population are suffering from sickle-cell anaemia. Sickle cell disease is caused by a mutation in the haemoglobin-Beta gene found on chromosome 11. Sickle cell anaemia is controlled by a pair of alleles, H and h, where the individuals with the illness have the homozygous recessive genotype; those with normal red blood cells have the alternative genotype. Using the Hardy-Weinberg's equation, calculate the percentage of the population of the two genotypes for normal blood cells. In a few remote areas in that country, the percentage of sickle cell anaemia reaches as high as 5%. Calculate the percentage of homozygous and heterozygous individuals with the normal blood cells and find the ratio for both phenotypes. Discuss whether blood cells go through mitosis.

Q: In Alaskan Malamute dogs, an autosomal recessive allele causes a condition in which the cartilage in…

A: There are two characters the height and the shape of tail. Let's represent the dominant allele for…

Q: Regarding Mendelian inheritance in diploid individuals, (Read each statement carefully. Select all…

A: Ploidy is a term which describe the number of sets of chromosomes in a cell. The term haploid…

Q: Glucose-6-phosphate dehydrogenase (G6PD)-deficiency is another human red blood cell disease that…

A: The alleles are the alternative forms of a gene that are located on the same locus of a homologous…

Q: ake the example of B-thalassemia, an autosomal recessive genetic disease that particularly affects…

A: A point mutation is a change in the single nucleotide pair of DNA.

Q: A genetic disorder is caused by a LOF mutation (Bm) and epigenetic imprinting of gene B. Through…

A: Epigenetic imprinting or genomic imprinting is a process where there is the exclusive expression of…

Q: Hemophilia is caused by an X-linked recessive mutation in humans. If a woman whose paternal uncle…

A: In the disease called “haemophilia”, if a wound is created, the blood does not clot normally. This…

Q: Marfan syndrome is a disease caused by a rare dominant allele of the fibrillin-1 gene. Fibrillin-1…

A: Marfan syndrome refers to the genetic disorder related to connective tissue characterized by tall…

Q: In a study of a muscle disorder, several affected families exhibited vision problems, muscle…

A: Genes in nuclear content express most of the characters, while some of the characters are associated…

Q: Many genetic disorders exhibit locus heterogeneity. Define andgive two examples of locus…

A: Locus heterogeneity is a phenomenon in which a particular disease is caused by mutations in…

Q: A possible explanation for the increased incidence of Tay-Sachs disease among Ashkenazi Jews is

A: Tay Sachs is a rare autosomal recessive disorder that causes mental and physical disabilities…

Q: 1) Thalassaemia is a form of anaemia common in Mediterranean populations and resulting from a…

A: The body doesn't make enough protein called hemoglobin, due to an inherited disorder called…

Q: It is assumed that in Drosophila the following genotypes produce phenotypes. َA- B- = Red color A-…

A: Genetics may be a discipline of biology concerned with the study of genes, genetic diversity, and…

Q: A research team genotyped hundreds of families affected by haemophilia. Among those families, they…

A: RFLP is found on X chromosome and it is a sex-linked recessive disorder. The daughter who inherited…

Q: Lesch-Nyhan syndrome is due to a mutation in a gene that encodesa protein called…

A: Pedigree or family tree is a representation of an individual in a family or close relatives that…

Q: Anastasia was the youngest daughter of Czar Nicholas II of Russia. She had no known children, and…

A: Haemophilia is a sex-linked recessive disorder. The abnormal gene responsible for haemophilia is…

Q: Calculate genotypes and phenotypes in monohybrid crosses of traits with non-Mendelian inheritance…

A: The alleles are the alternative forms of a gene that are located on the same locus of a homologous…

Q: In humans, blood type is inherited based on multiple alleles in which type A and type B are dominant…

A: Note: First question is incomplete and upload it separately. In pea plants, round seeds are dominant…

Q: Two different variants (alleles) of ß-globin are found in African populations that offer some…

A: Hardy Weinberg’s principle is the mathematical representation of population analysis which…

Q: A recessive maternal effect mutant in zebrafish, called ichabod, results in embryos lacking heads…

A: The correct answer is option C.

Q: Below is a pedigree of a human genetic disease in which solid color indicates affected individuals.…

A: In the given pedigree, atleast one member in all generations have the disease. Therefore,…

Q: 1. Draw the pedigree for Amita's family and determine the mode of inheritance if any. 2. Explain how…

A: From the given data, it is clear that the disease is autosomal, not sex-linked. As if it was…

Q: In the species Polyfarius obscescens, one gene controls lipid storage. Individuals with the dominant…

A: Storage lipids, also known as triacylglycerols, membrane lipids, which include glycerophospholipids…

Q: The attached image is a pedigree of a family with a history of sickle cell anemia (the individuals…

A: Sickle cell anemia is a genetic condition caused by a mutation in the gene that codes for…

Q: One particularly useful feature of the Hardy-Weinberg equation is that it allows us to estimate the…

A: Hardy-Weinberg equilibrium states that, in a population allele and genotypic frequencies will remain…

Q: How would present allele frequencies of the sickle cell allele change, if there was no heterozygote…

A: Sickle cell anemia/SCA is an inherited-hematological disorder that significantly affects the shape…

Q: woman who is a carrier of sickle-cell trait (making her a heterozygote) has children with a man who…

A: Sickle cell anemia is an autosomal recessive disorder. There is a mutation in the single base pair…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.