Tay-Sachs disease is a rare human disease in which toxic substances accumulate in nerve cells. The recessive allele responsible for the disease is inherited in a simple Mendelian manner. For unknown reasons, the allele is more common in populations of Ashkenazi Jews of eastern Europe. A woman is planning to marry her first cousin, but the couple discovers that their shared grandfather’s sister died in infancy of Tay-Sachs disease. a. Draw the relevant parts of the pedigree, and show all the genotypes as completely as possible. b. What is the probability that the cousins’ first child will have Tay-Sachs disease, assuming that all people who marry into the family are homozygous normal?

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Inheritance and Mendelian Genetics

Inheritance means the passing of traits to offspring from parents. These traits could be passed either through asexual reproduction or sexual reproduction. The offspring receives the genetic material from the parents. Mendelian inheritance is a certain biological inheritance that follows the rules and principles laid down by Gregor Mendel in 1865. The initial hypothesis was considered wrong, but other inheritance theories modified the concept of inheritance and thus genetics.