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F1 mice targeted using CRISPR/Cas9 and an HDR DNA fragment is the first choice when modeling a. Autosomal dominant disorders due to missense mutations b. Autosomal recessive disorders due to knockout mutations C. Autosomal dominant disorders due to haploinsufficiency d. X-linked recessive disorders in females e. Autosomal recessive disorders due to missense mutations

F1 mice targeted using CRISPR/Cas9 and an HDR DNA fragment is the first choice when modeling a. Autosomal dominant disorders due to missense mutations b. Autosomal recessive disorders due to knockout mutations C. Autosomal dominant disorders due to haploinsufficiency d. X-linked recessive disorders in females e. Autosomal recessive disorders due to missense mutations

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Title: Targeting F1 Mice with CRISPR/Cas9 and HDR DNA Fragment Selection for Disease Modeling Summary: In genetic research, F1 mice constructed using CRISPR/Cas9 technology paired with a homology-directed repair (HDR) DNA fragment are frequently preferred for modeling various genetic disorders. Below are five different categories of genetic disorders presented for targeting using these techniques: Multiple Choice Question: Which type of genetic disorder is best modeled by targeting F1 mice using CRISPR/Cas9 and an HDR DNA fragment? Options: a. Autosomal dominant disorders due to missense mutations b. Autosomal recessive disorders due to knockout mutations c. Autosomal dominant disorders due to haploinsufficiency d. X-linked recessive disorders in females e. Autosomal recessive disorders due to missense mutations Explanation of Terms: 1. **Autosomal Dominant Disorders (Missense Mutations)**: These disorders occur when a single missense mutation in one allele of a gene on an autosome (non-sex chromosome) causes disease. 2. **Autosomal Recessive Disorders (Knockout Mutations)**: Here, the disorder manifests only when both alleles of a gene contain knockout mutations, leading to a complete loss of gene function. 3. **Autosomal Dominant Disorders (Haploinsufficiency)**: These disorders occur when a single functional copy of a gene is insufficient for maintaining normal function. 4. **X-linked Recessive Disorders in Females**: These are conditions where a mutation occurs on the X chromosome, with effects typically more pronounced in females. 5. **Autosomal Recessive Disorders (Missense Mutations)**: In these diseases, missense mutations in both copies of a gene result in a functional defect, causing the disorder. Please select the most suitable option from the list provided for modeling genetic disorders using CRISPR/Cas9 and an HDR DNA fragment technique in F1 mice.
Transcribed Image Text:Title: Targeting F1 Mice with CRISPR/Cas9 and HDR DNA Fragment Selection for Disease Modeling Summary: In genetic research, F1 mice constructed using CRISPR/Cas9 technology paired with a homology-directed repair (HDR) DNA fragment are frequently preferred for modeling various genetic disorders. Below are five different categories of genetic disorders presented for targeting using these techniques: Multiple Choice Question: Which type of genetic disorder is best modeled by targeting F1 mice using CRISPR/Cas9 and an HDR DNA fragment? Options: a. Autosomal dominant disorders due to missense mutations b. Autosomal recessive disorders due to knockout mutations c. Autosomal dominant disorders due to haploinsufficiency d. X-linked recessive disorders in females e. Autosomal recessive disorders due to missense mutations Explanation of Terms: 1. **Autosomal Dominant Disorders (Missense Mutations)**: These disorders occur when a single missense mutation in one allele of a gene on an autosome (non-sex chromosome) causes disease. 2. **Autosomal Recessive Disorders (Knockout Mutations)**: Here, the disorder manifests only when both alleles of a gene contain knockout mutations, leading to a complete loss of gene function. 3. **Autosomal Dominant Disorders (Haploinsufficiency)**: These disorders occur when a single functional copy of a gene is insufficient for maintaining normal function. 4. **X-linked Recessive Disorders in Females**: These are conditions where a mutation occurs on the X chromosome, with effects typically more pronounced in females. 5. **Autosomal Recessive Disorders (Missense Mutations)**: In these diseases, missense mutations in both copies of a gene result in a functional defect, causing the disorder. Please select the most suitable option from the list provided for modeling genetic disorders using CRISPR/Cas9 and an HDR DNA fragment technique in F1 mice.
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