10. Fur colour in mice is an example of the effects of interaction between different genes. Wild type mice have agouti fur where the individual hairs are black with a yellow band producing the typical grey-like colour of agouti fur. Two different independently segregating genes are involved in the expression of coat colour: • A single gene with two alleles, A and a, determines the colour of the coat; Agouti (AA or Aa) is dominant over black (aa). • A different gene is required for the hair pigment to be synthesised and therefore expressed. When the dominant allele of this gene is present (C), pigment is produced and the agouti and black phenotypes can be expressed. A null allele (c, which produces an inactive form of the enzyme for pigment production) is recessive; when in the homozygous form (cc), no pigment is produced and the mice are albino. a) Write down the colour of the coat of mice with the following genotypes: Genotype Phenotype aaCc b) Consider the following cross: Parents Black x Albino Gametes F1 generation AaCC aaCC aC AaCc X X Aacc AAcc Ac All agouti Use a Punnet square to determine the genotypes and then the phenotypic ratio expected in the F2 generation when the F₁ agouti mice are interbred.
10. Fur colour in mice is an example of the effects of interaction between different genes. Wild type mice have agouti fur where the individual hairs are black with a yellow band producing the typical grey-like colour of agouti fur. Two different independently segregating genes are involved in the expression of coat colour: • A single gene with two alleles, A and a, determines the colour of the coat; Agouti (AA or Aa) is dominant over black (aa). • A different gene is required for the hair pigment to be synthesised and therefore expressed. When the dominant allele of this gene is present (C), pigment is produced and the agouti and black phenotypes can be expressed. A null allele (c, which produces an inactive form of the enzyme for pigment production) is recessive; when in the homozygous form (cc), no pigment is produced and the mice are albino. a) Write down the colour of the coat of mice with the following genotypes: Genotype Phenotype aaCc b) Consider the following cross: Parents Black x Albino Gametes F1 generation AaCC aaCC aC AaCc X X Aacc AAcc Ac All agouti Use a Punnet square to determine the genotypes and then the phenotypic ratio expected in the F2 generation when the F₁ agouti mice are interbred.
Human Anatomy & Physiology (11th Edition)
11th Edition
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
Section: Chapter Questions
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Transcribed Image Text:10. Fur colour in mice is an example of the effects of interaction between different genes.
Wild type mice have agouti fur where the individual hairs are black with a yellow
band producing the typical grey-like colour of agouti fur.
Two different independently segregating genes are involved in the expression of coat
colour:
• A single gene with two alleles, A and a, determines the colour of the coat; Agouti
(AA or Aa) is dominant over black (aa).
• A different gene is required for the hair pigment to be synthesised and therefore
expressed. When the dominant allele of this gene is present (C), pigment is
produced and the agouti and black phenotypes can be expressed. A null allele
(c, which produces an inactive form of the enzyme for pigment production) is
recessive; when in the homozygous form (cc), no pigment is produced and the
mice are albino.
a) Write down the colour of the coat of mice with the following genotypes:
Genotype
Phenotype
aaCc
b) Consider the following cross:
Parents
Black x Albino
Gametes
F1 generation
AaCC
aaCC
aC
AaCc
X
X
Aacc
AAcc
Ac
All agouti
Use a Punnet square to determine the genotypes and then the phenotypic ratio
expected in the F₂ generation when the F₁ agouti mice are interbred.
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