Q. 3: In rats, the following genotypes of two independently assorting autosomal genes determine cont color: A-B- (gray) A-bb (yellow) aab (black) aabb (cream) A third gene pair on a separate autosome determines whether or not any color will be produced. The CC and Ce genotypes allow color according to the expression of the A and B alleles. However, the ce genotype results in albino rats regardless of the A and B alleles present. Determine the Fl phenotypic ratio of the following crosses: (a) AAbbCC x aaBBcc (b) AaBBCC x AABbce (c) AaBbCc x AaBbcc

Q. 3: In rats, the following genotypes of two independently assorting autosomal genes determine cont color: A-B- (gray) A-bb (yellow) aab (black) aabb (cream) A third gene pair on a separate autosome determines whether or not any color will be produced. The CC and Ce genotypes allow color according to the expression of the A and B alleles. However, the ce genotype results in albino rats regardless of the A and B alleles present. Determine the Fl phenotypic ratio of the following crosses: (a) AAbbCC x aaBBcc (b) AaBBCC x AABbce (c) AaBbCc x AaBbcc

Name: Q. 3: In rats, the following genotypes of two independently assorting
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Description: Q. 3: In rats, the following genotypes of two independently assorting autosomal genes determine cont color: A-B- (gray) A-bb (yellow) aab (black) aabb (cream) A third gene pair on a separate autosome determines whether or not any color will be produc

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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. The human IGF2 gene is autosomal and maternallyimprinted. Copies of the gene received from themother are not expressed, but copies received fromthe father are expressed. You have found two allelesof this gene that encode two different forms of theIGF2 protein distinguishable by gel electrophoresis.One allele encodes a 60K (Kilodalton) blood protein;the other allele encodes a 50K blood protein. In ananalysis of blood proteins from a couple named Billand Joan, you find only the 60K protein in Joan’sblood and only the 50K protein in Bill’s blood. Youthen look at their children: Jill is producing only the50K protein, while Bill Jr. is producing only the 60Kprotein.a. With these data alone, what can you say about theIGF2 genotype of Bill Sr. and Joan?b. Bill Jr. and a woman named Sara have two children, Pat and Tim. Pat produces only the 60K protein and Tim produces only the 50K protein. Withthe accumulated data, what can you now say aboutthe genotypes of Joan and Bill Sr.?
In rats, the following genotypes of two independently assorting autosomal genes determine coat color: A_B_ (gray); A_bb (yellow); aaB_ (black); aabb (cream). A third gene pair on a separate autosome determines whether or not any color will be produced. The CC and Cc genotypes allow color according to the expression of the A and B alleles. However, the cc genotype results in albino rats regardless of the A and Balleles present. Determine the F1 phenotypic ratio of the following crosses: (a) AAbbCC x aaBBcc; (b) AAbbCC x aaBBcc; (c) AABBCC x AABbcc.
AaBbCc x AaBbcc How would you characterize this kind of relationship between the genes: A-B- (gray); A-bb (yellow); aaB- (black); aabb (cream) The CC and Cc genotypes allow color according to the expression of the A and B alleles. However, the cc genotype results in albino rats regardless of the A and B alleles present
A complex biochemical pathway is shown below, along with the alleles that either promote or inhibit each step of the pathway leading to a phenotype. Gene A has alleles A and a, B has alleles B and b, and so forth. Genes B and C are duplicate dominant epistatic lethal as heterozygotes (i.e. Bb Cc are lethal). Genes D and E are duplicate dominant epistatic (i.e. dd eg = desired phenotype). If I were to cross AA Bb cc Dd Ee with aa BB Cc Dd e, (i) (ii) What proportion of all offspring don't show the phenotype? What proportion of offspring survive? Gene A Gene B B Gene D a Gene C Gene E
Concordance studies of twins for a neurodegenerative disorder show MZ= 46% and DZ= 15%. Further studies have shown a possible link to a gene on chromosome 9, however, there are some individuals in the study who have the allele but do not develop the disorder (group 1), and there are other individuals who do not have the allele yet develop the disorder (group 2). Amita's older sister and maternal uncle have this disorder. Currently, Amita & her 2 younger brothers do not show symptoms. Amita's paternal grandfather was rumored to have this disorder. 1. Draw the pedigree for Amita's family and determine the mode of inheritance if any. 2. Explain how the 2 groups in the study could be possible? 3. What would you tell Amita about the heritability of this disorder?
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In humans, dosage compensation is accomplished by: inactivating one X chromosome in female somatic cells inactivating one homolog from each homologous pair of chromosomes in female somatic cells inactivating the Y chromosome in male somatic cells increasing gene expression from the X chromosome in male somatic cell
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Duchenne Muscular Dystrophy (DMD) is a disorder that primarily affects the function of skeletal muscles used for movement and cardiac muscles used for heart beating. Dystrophin is a protein encoded by a single gene, DMD, that is expressed in skeletal and cardiac muscle. Some forms of muscular dystrophy may be caused by different mutations in the DNA sequence of the DMD gene. Because the DMD locus is on the X chromosome, males are affected at higher rates. Two brothers, one of whom has DMD and one of whom does not, worked with their genetic counselor (Links to an external site.) to have their DMD gene sequenced to identify genetic variation that may explain why one brother was affected and the other not. Because DMD is a very long gene, a fictionalized, simplified model of the results is presented here (Figure 1). The actual DMD mRNA is about 16,000 base-pairs!------Consider single nucleotide polymorphism (SNP) #1 (Figure 1). Is this mutation likely to cause Duchenne muscular…
10. Fur colour in mice is an example of the effects of interaction between different genes. Wild type mice have agouti fur where the individual hairs are black with a yellow band producing the typical grey-like colour of agouti fur. Two different independently segregating genes are involved in the expression of coat colour: • A single gene with two alleles, A and a, determines the colour of the coat; Agouti (AA or Aa) is dominant over black (aa). • A different gene is required for the hair pigment to be synthesised and therefore expressed. When the dominant allele of this gene is present (C), pigment is produced and the agouti and black phenotypes can be expressed. A null allele (c, which produces an inactive form of the enzyme for pigment production) is recessive; when in the homozygous form (cc), no pigment is produced and the mice are albino. a) Write down the colour of the coat of mice with the following genotypes: Genotype Phenotype aaCc b) Consider the following cross: Parents…
10. Fur colour in mice is an example of the effects of interaction between different genes. Wild type mice have agouti fur where the individual hairs are black with a yellow band producing the typical grey-like colour of agouti fur. Two different independently segregating genes are involved in the expression of coat colour: • A single gene with two alleles, A and a, determines the colour of the coat; Agouti (AA or Aa) is dominant over black (aa). • A different gene is required for the hair pigment to be synthesised and therefore expressed. When the dominant allele of this gene is present (C), pigment is roduced and the agouti and black phenotypes can be expressed. A null allele (c, which produces an inactive form of the enzyme for pigment production) is recessive; when in the homozygous form (cc), no pigment is produced and the mice are albino. a) Write down the colour of the coat of mice with the following genotypes: Genotype Phenotype aaCc b)Consider the following cross: Parents…