Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # ____ and ____ of Pyruvate are added to the co-enzyme ______ and whereas Carbon # ______ leaves as CO. The C-2 unit together with the co-enzyme is called ______ .The C-2 unit is then transferred to the 2nd co-enzyme ____, which is initially in it ___ state. The enzyme that catalyzes this step is ______.From here, the C-2 unit is transferred to form a _____ linkage with CoA-SH to generate_____

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time.

Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # ____ and ____ of Pyruvate are added to the co-enzyme ______ and whereas Carbon # ______ leaves as CO.

The C-2 unit together with the co-enzyme is called ______ .The C-2 unit is then transferred to the 2nd co-enzyme ____, which is initially in it ___ state. The enzyme that catalyzes this step is ______.From here, the C-2 unit is transferred to form a _____ linkage with CoA-SH to generate_____

Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using
words provided. Not all words will be used. Each word will be used only one time.
Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl
CoA from Pyruvate. First, a 2-carbon unit composed of Carbons #
and
of
whereas Carbon #
Pyruvate are added to the co-enzyme
leaves as CO₂.
The C-2 unit together with the co-enzyme is called
transferred to the 2nd
co-enzyme
Acetyl CoA
Oxidized
Hydroxyethyl TPP
Lipoamide
state. The enzyme that catalyzes this step is
linkage with CoA-SH to generate
Phosphodiester
Reduced
Hydroxypropionyl
TPP
E-1
From here, the C-2 unit is transferred to form a
NADH
3
Dihydrolipoyl
dehydrogenase
Thioester
The C-2 unit is then
which is initially in its
2
Hydroxyacetyl TPP
Dihydropipoyl
Transacetylase
Transcribed Image Text:Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # and of whereas Carbon # Pyruvate are added to the co-enzyme leaves as CO₂. The C-2 unit together with the co-enzyme is called transferred to the 2nd co-enzyme Acetyl CoA Oxidized Hydroxyethyl TPP Lipoamide state. The enzyme that catalyzes this step is linkage with CoA-SH to generate Phosphodiester Reduced Hydroxypropionyl TPP E-1 From here, the C-2 unit is transferred to form a NADH 3 Dihydrolipoyl dehydrogenase Thioester The C-2 unit is then which is initially in its 2 Hydroxyacetyl TPP Dihydropipoyl Transacetylase
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