The reactions of the pyruvate dehydrogenase complex are required to generate the substrate that is fed into the TCA (Kreb’s) cycle from pyruvate. The 3 enzymes that make up this complex are pyruvate dehydrogenase (E1), dihydrolipoyl transacetylase (E2) dihydrolipoyl dehydrogenase (E3). a. Name the one diffusible reaction product (i.e. the product that is free to leave the enzyme complex) of
The reactions of the pyruvate dehydrogenase complex are required to
generate the substrate that is fed into the TCA (Kreb’s) cycle from pyruvate. The 3
enzymes that make up this complex are pyruvate dehydrogenase (E1), dihydrolipoyl
transacetylase (E2) dihydrolipoyl dehydrogenase (E3).
a. Name the one diffusible reaction product (i.e. the product that is free to leave
the enzyme complex) of each enzyme of the complex.
b. Draw the “business end” of the fully reduced form of lipoic acid.
c. Using words, fully describe the function of E3 in this complex. Your answer
should include all cofactors used, all intermediates and products of this enzyme.
DO NOT show any mechanisms for this part.
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