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NAD* NADH Pyruvate Acetyl-CoA CoA CO₂

NAD* NADH Pyruvate Acetyl-CoA CoA CO₂

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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The pyruvate dehydrogenase complex catalyzes the synthesis of acetyl-CoA, a very important molecule in cellular metabolism. The reaction catalyzed by the pyruvate dehydrogenase enzyme complex is shown below. This reaction is tightly regulated, because it is essentially irreversible.

Which of the following conditions is most likely to lead to the inhibition of pyruvate dehydrogenase in cells? (select two answers)

  1. High concentrations of acetyl-CoA
  2. High concentrations of pyruvate
  3. High concentrations of NADH
  4. High concentrations of NAD+
  5. High concentrations of CoA
NAD* NADH Pyruvate Acetyl-CoA CoA CO₂
Transcribed Image Text:NAD* NADH Pyruvate Acetyl-CoA CoA CO₂
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