Citrate synthase is regulated by another metabolite that has the opposite effect (i.e., stimulates citrate synthase). Choose the description of a condition where a positive regulator activates citrate synthase. Low [ATP/ADP] ratio. ADP is an allosteric activator of citrate synthase. High [citrate]. Citrate is a positive allosteric activator. High [NADH/NAD*] ratio. NADH is a positive allosteric activator. High [ATP/ADP] ratio. High ATP substrate levels favor product formation.
Citrate synthase is regulated by another metabolite that has the opposite effect (i.e., stimulates citrate synthase). Choose the description of a condition where a positive regulator activates citrate synthase. Low [ATP/ADP] ratio. ADP is an allosteric activator of citrate synthase. High [citrate]. Citrate is a positive allosteric activator. High [NADH/NAD*] ratio. NADH is a positive allosteric activator. High [ATP/ADP] ratio. High ATP substrate levels favor product formation.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
100%
In the presence of saturating amounts of oxaloacetate, the activity of citrate synthase from pig heart tissue shows a sigmoid dependence on the concentration of acetyl‑CoA. When succinyl‑CoA is added, the curve shifts to the right and the sigmoid dependence is more pronounced.
![Activity (% of Vmax)
100F No
80
60
40
20
I
succinyl-CoA
Succinyl-CoA
added
1
20 40 60 80 100 120
[Acetyl-CoA] (um)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F13a5a00a-4cb0-4c6a-93d2-f1168bf2c021%2F5bbaeb62-cc6d-42a3-bcb2-9a5f659b8a79%2F8n5gye_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Activity (% of Vmax)
100F No
80
60
40
20
I
succinyl-CoA
Succinyl-CoA
added
1
20 40 60 80 100 120
[Acetyl-CoA] (um)
![Citrate synthase is regulated by another metabolite that has
the opposite effect (i.e., stimulates citrate synthase).
Choose the description of a condition where a positive
regulator activates citrate synthase.
Low [ATP/ADP] ratio. ADP is an allosteric
activator of citrate synthase.
High [citrate]. Citrate is a positive
allosteric activator.
High [NADH/NAD*] ratio. NADH is a positive
allosteric activator.
High [ATP/ADP] ratio. High ATP substrate levels
favor product formation.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F13a5a00a-4cb0-4c6a-93d2-f1168bf2c021%2F5bbaeb62-cc6d-42a3-bcb2-9a5f659b8a79%2Fdg59ve_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Citrate synthase is regulated by another metabolite that has
the opposite effect (i.e., stimulates citrate synthase).
Choose the description of a condition where a positive
regulator activates citrate synthase.
Low [ATP/ADP] ratio. ADP is an allosteric
activator of citrate synthase.
High [citrate]. Citrate is a positive
allosteric activator.
High [NADH/NAD*] ratio. NADH is a positive
allosteric activator.
High [ATP/ADP] ratio. High ATP substrate levels
favor product formation.
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