Fatty acid synthesis requires the activation of acetyl CoA tomalonyl CoA. However, its condensation with a fatty acyl ACPresults in the addition of only its two carbons. What is thethermodynamic advantage of the activation reaction?. The condensing enzyme requires a 3-carbon compound assubstrate.Cleavage of CO2 from malonyl CoA provides the energy toallow for condensation to occur.It is the activate form of the two carbon acetyl CoAnecessary for condensation.It makes malonyl CoA unstable.The reaction is a reversal of the 2-oxidation which is aspontaneous process.

Fatty acids are broken down to acetyl Co-A and the precursor for the fatty acid synthesis is acetyl…

Answered: Fatty acid synthesis requires the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Which of the following statements is TRUE about fatty acid biosynthesis? Citrate carries malonyl CoA to the cytosol. O Acetyl ACP is the donor of the acetyl group. O NADPH is used as the reducing equivalent in the process. O The product detaches from the fatty acid synthase complex when the chain length is usually 18 carbons.
Beta-Oxidation of a 15:14⁹ fatty acid will result in the production of which of the following? 7 acetyl CoA, 1 propionyl CoA, 6 FADH2 and 6 NADH 7 acetyl CoA, 6 FADH2 and 6 NADH 6 acetyl CoA, 1 propionyl CoA, 6 FADH2 and 6 NADH 6 acetyl CoA, 1 propionyl CoA, 5 FADH2 and 6 NADH 6 acetyl CoA, 6 FADH2 and 6 NADH
A biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B: in the mechanism.
Which of the following statements inaccurately describes glutamate dehydrogenase? Glutamate dehydrogenase uses either NAD+ or NADP+ in a redox reaction Glutamate dehydrogenase catalyzes an oxidative deamination reaction Glutamate dehydrogenase equilibrium lies with the reductive amination of glutamate Glutamate dehydrogenase utilizes hydrolysis to release ammonium from an imine intermediate
Which of the following statements is TRUE about fatty acid biosynthesis? Group of answer choices: NADH is used as the reducing equivalent in the process. Malonyl ACP is the donor of the acetyl group. The product detaches from the fatty acid synthase complex when the chain length is usually 18 carbons. Oxaloacetate carries acetyl CoA to the cytosol.
Mechanistically, how does NADPH facilitate the removal of an oxygen atom from intermediates in fatty acid synthesis?
Match the following B vitamins with the roles of their coenzymes: riboflavin [ Choose ] niacin [ Choose ] pantothenic acid [ Choose ] vitamin B6 [ Choose ]
In the beta oxidation of linoleic acid, converting the 3, 5, 8 trienoyl CoA intermediate back to an expected intermediate for a beta oxidation substrate costs the equivalent of how many ATPs? (hint: look at the 'right side' of the figure for addressing problem 3 with linoleic acid)
Which one of the following regarding the chemistry of glycolysis & gluconeogenesis is FALSE? Reaction 6 of glycolysis catalyzed by glyceraldehyde-3-phosphate dehydrogenase involves oxidation & addition of a P; group. Reaction 3 of gluconeogenesis catalyzed by enolase involves hydration, the addition of water to a carbon-carbon double bond (C=C) to form an alcohol. Reaction 1 of gluconeogenesis catalyzed by pyruvate carboxylase involves decarboxylation. Reaction 9 of gluconeogenesis catalyzed by fructose-1,6-bisphosphatase involves dephosphorylation (phosphoester hydrolysis). Reaction 1 of glycolysis catalyzed by hexokinase involves phosphorylation (using ATP). O 0000
Describe how a) Mean Arterial Pressure, b) Maximal Oxygen Consumption, and c) Blood Flow are determined using its formula. In addition, you should explain what those factors are including cardiac output, stroke volume, heart rate, resistance, a-vO2 difference, etc. Describe how many ATPs can be generated by complete cycles of beta oxidation of free fatty acid with 20 carbons. You should indicate how many cycles of beta oxidation and Krebs cycle, and total number of products as well
The citrate cycle is a metabolic engine generating [ Select: "carbon monoxide", "NAD, FAD and GDP", "carbon dioxide, NADH, FADH, and GTP"] from the fuel [ Select : "triglycerides", "acetyl-CoA"]. It is considered a cycle since all components must be maintained beginning with the addition of the two carbons from acetyl-CoA to form [ Select ] ["succinate", "citrate"] from [ Select ]["fumarate", "oxaloacetate"]. The citrate cycle depends on the presence of oxygen since [ Select ]["oxygen is directly required in the citrate cycle", "oxygen is required for NADH and FADH2 oxidation, and their accumulation in the absence of electron transport results in feedback inhibition of the citrate cycle"] .
Coenzyme A (CoA-SH) plays an important role in the Pyruvate Dehydrogenase Complex reaction. Which is correct? Coenzyme A serves as an electron acceptor in this reaction. The hydrolysis of a CoA thioester has a positive AG", the hydrolysis is endergonic and unfavorable. Coenzyme A is derived from thiamine, a vitamin. Coenzyme A contains -SH group and can serve as an acyl group carrier.

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