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Which of the following statements is true for the shown reaction?   The reaction is shared by ketone body synthesis and cholesterol biosynthesis The chemical in box B is NAD+ The reaction predominantly occurs in the liver All of the above None of the above

Which of the following statements is true for the shown reaction?   The reaction is shared by ketone body synthesis and cholesterol biosynthesis The chemical in box B is NAD+ The reaction predominantly occurs in the liver All of the above None of the above

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Which of the following statements is true for the shown reaction?

 

The reaction is shared by ketone body synthesis and cholesterol biosynthesis

The chemical in box B is NAD+

The reaction predominantly occurs in the liver

All of the above

None of the above

### Metabolic Pathway Representation In this diagram, we represent a biochemical transformation involving metabolic intermediates and enzymes. 1. **Starting Compound (W)**: - The molecule on the left side is labeled as "W" and has the following structure: - Contains a carbonyl group (C=O) linked to an S-CoA group (coenzyme A). - Attached to a butanediol group: - CH2 (methylene group) - CH with a hydroxyl group (H3C-C-OH) - CH2 (methylene group) - Carboxylate group (COO^-). 2. **Transformation Process**: - This molecule undergoes a biochemical transformation mediated by two potential pathways involving enzymes marked as "A" and "B". - The arrows from boxes "A" and "B" indicate the direction of enzyme action. 3. **Enzyme "A"**: - Leads to direct transformation of compound "W". 4. **Enzyme "B"**: - Facilitates the release of HS-CoA (reduced Coenzyme A) as a product/byproduct from the initial compound "W". 5. **Final Compound (Y)**: - The resulting product from this metabolic reaction is labeled as "Y". - Y has a similar structure to W but without the S-CoA portion: - Contains: - CH2 (methylene group) - CH with a hydroxyl group (H3C-C-OH) - CH2 (methylene group) - Carboxylate group (COO^-). ### Detailed Explanation: This representation illustrates a crucial step in metabolic pathways where a substrate "W", which initially carries a Coenzyme A (CoA) group, is converted into a product "Y" by enzymatic actions. The enzymes (A and B) catalyze specific steps either directly leading to the product or by intermediate steps involving release of CoA. This release of HS-CoA (reduced form) indicates that the CoA group has been cleaved from compound "W" as part of the transformation process. This kind of metabolic mapping is essential for understanding various biochemical cycles such as the Citric Acid Cycle, Fatty Acid β-oxidation, or synthesis pathways.
Transcribed Image Text:### Metabolic Pathway Representation In this diagram, we represent a biochemical transformation involving metabolic intermediates and enzymes. 1. **Starting Compound (W)**: - The molecule on the left side is labeled as "W" and has the following structure: - Contains a carbonyl group (C=O) linked to an S-CoA group (coenzyme A). - Attached to a butanediol group: - CH2 (methylene group) - CH with a hydroxyl group (H3C-C-OH) - CH2 (methylene group) - Carboxylate group (COO^-). 2. **Transformation Process**: - This molecule undergoes a biochemical transformation mediated by two potential pathways involving enzymes marked as "A" and "B". - The arrows from boxes "A" and "B" indicate the direction of enzyme action. 3. **Enzyme "A"**: - Leads to direct transformation of compound "W". 4. **Enzyme "B"**: - Facilitates the release of HS-CoA (reduced Coenzyme A) as a product/byproduct from the initial compound "W". 5. **Final Compound (Y)**: - The resulting product from this metabolic reaction is labeled as "Y". - Y has a similar structure to W but without the S-CoA portion: - Contains: - CH2 (methylene group) - CH with a hydroxyl group (H3C-C-OH) - CH2 (methylene group) - Carboxylate group (COO^-). ### Detailed Explanation: This representation illustrates a crucial step in metabolic pathways where a substrate "W", which initially carries a Coenzyme A (CoA) group, is converted into a product "Y" by enzymatic actions. The enzymes (A and B) catalyze specific steps either directly leading to the product or by intermediate steps involving release of CoA. This release of HS-CoA (reduced form) indicates that the CoA group has been cleaved from compound "W" as part of the transformation process. This kind of metabolic mapping is essential for understanding various biochemical cycles such as the Citric Acid Cycle, Fatty Acid β-oxidation, or synthesis pathways.
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