One of the steps in psilocybin biosynthesis is the phosphorylation of 4-hydroxytryptamineBy the enzyme Psik as shown below, that involves the hydrolysis of ATP.NH₂OHHOPsikHOof A&ADP4-hydroxytryptamineATPnorbaeocystinThe standard free energy changes for each reaction is shown in the Table below.Jreaction4-hydroxytryptamine + P₁ → norbaeocystinATP → ADP+ Pi(b) What is the equilibrium constant at 37 °C?AG27.7 kJ/mol-32.2 kJ/mol(a) Write the net reaction. What is the standard free energy change for the net reaction?(c) In the cell, the concentration of ATP is 3.1 mM, the concentration of P; Is 5.90 mM, and theConcentration of ADP is 220 μM. What will AG Be if the concentration of norbaeocystinIs always kept at 1/100 of the concentration of 4-hydroxytryptamine?

In a general reaction such as: aA + bB ⇌ cC + dD At equilibrium (steady state), the concentration of…

Answered: One of the steps in psilocybin…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Just 15-3
All of the following products of biosynthesis are nitrogen-rich tetrapyrrole structures that can be synthesized from Krebs cycle intermediates (in some plants, animals, or bacteria), with the exception of: triglyceride molecules chlorophyll b molecules vitamin B12 molecules chlorophyll a molecules heme molecules Identify the Krebs cycle enzyme that consumes a six-carbon substrate molecule, producing a five-carbon product molecule along with NADH, and one molecule of CO2. succinyl CoA synthetase a-ketoglutarate dehydrogenase malate dehydrogenase isocitrate dehydrogenase citrate synthase
A figure of the energy payoff phase of glycolysis is shown below. Look at the reaction labelled with a 6 (on the far left), which involves the conversion of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate. reduced? HC O CHOH CH₂O-P Glycer- aldehyde 3-phosphate (G3P) 2 NADH 2 NAD+ + 2 H+ Triose phosphate 2 P₁ dehydrogenase Copyright © 2018 Pearson Canada Inc. P CHOH CH₂0-P 1,3-Bisphospho- glycerate 1,3- bisphosphoglycerate NADH NAD+ 2 ADP GLYCOLYSIS: Energy Payoff Phase Glyceraldehyde-3-phosphate 2 ATP Phospho- glycerokinase 2 Which of the compounds is C=O CHOH H–CO- P Phospho- CH₂0-P glyceromutase CH₂OH 8 3-Phospho- glycerate C=O 2-Phospho- glycerate 2. ATP 2 ADP BYD Pyruvate kinase 10 2 H₂O Enolase 2 C=O CO-P CH2 Phosphoenol- pyruvate (PEP) CH3 Pyruvate
The isoelectric point (pI) of 6-phosphogluconate dehydrogenase is 6.0. Explain why the buffer used in DEAE cellulose chromatography must have a pH greater than 6 but less than 9 in order for the enzyme to bind to the DEAE resin.
Select the single best answer. What reaction does the enzyme triose phosphate isomerase catalyze? Conversion of dihydroxyacetone phosphate into glyceraldehyde-3-phosphate. Isomerization of 3-phosphoglycerate into 2-phosphoglycerate. Substrate level phosphorylation involving transfer of a phosphoryl group from 1,3-bisphosphoglycerate into 3-phosphoglycerate. Isomerization of glucose-6-phosphate into fructose-6-phosphate.
Calculate the net charge of the the tripeptide Asp-Asp-Asp at pH 1.00? Please show me how to do it a. 0b. -3c. -4d. +1e. -2
4- Salicylamides are inhibitors for an enzyme called scytalone dehydratase. SAR shows that there are three important hydrogen bonding interactions. Explain whether you think quinazolines could act as a bioisostere for salicylamides. HBA OH O 00 N NHR Quinazolines Salicylamides Ph HBA 5- Structure IX (X = NH) is an inhibitor of a metalloenzyme called thermolysin and forms interactions as shown. Explain why the analogue (X = O) has reduced binding affinity by a factor of 1000 and why the analogue (X = SH) has roughly the same binding affinity. Structure IX H HBD Ala-113 R
Describe how the functional units for beta carotene, xanthophyll, chlorophyll A, and chlorophyll B are different. Be sure to identify the subunits that adhere to paper during chromatography.
Refer to Table to explain why FAD rather than NAD+ is used in the succinate dehydrogenase reaction.
We saw the oxidation/reduction of malate to/fro oxaloacetate in two pathways that we looked at: _____________________________________ and _________________________.
In different organisms sucrose can be cleaved either by hydrolysis or by phosphorolysis. Calculate the ATP yield per mole of sucrose metabolized by anaerobic glycolysis starting with (a) hydrolytic cleavage and (b) phosphorolytic cleavage.
Draw the products of the reaction of xylulose-5-phosphate and erythrose-4-phosphate catalyzed by transketolase in the pentose phosphate pathway. Provide the structure in the protonation state found in physiological conditions. H H H OH FO HO-H H-OH H OPO3²- Q transketolase Draw glyceraldehyde-3- phosphate H H- H H H O OH OH OPO3²- Draw fructose-6- phosphate Q I I

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