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A biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B: in the mechanism.

A biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B: in the mechanism.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B: in the mechanism.

A biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B : in the mechanism. COA -COA :0: :ö: -COA COA :$: S-COA S-COA COA *BH :S-COA :B *BH Step 1: Draw curved arrows to form the enolate. H,C COA H COA Incorrect Step 2: Draw curved arrows for the condensation step. H;C COA H,C COA + B - H 1L 1L
Transcribed Image Text:A biological Claisen reaction occurs in the conversion of two acetyl CoA molecules to one acetoacetyl CoA. Analyze each step of the incomplete mechanism and add the missing curved arrows. The base is abbreviated as B : in the mechanism. COA -COA :0: :ö: -COA COA :$: S-COA S-COA COA *BH :S-COA :B *BH Step 1: Draw curved arrows to form the enolate. H,C COA H COA Incorrect Step 2: Draw curved arrows for the condensation step. H;C COA H,C COA + B - H 1L 1L
Step 3: Draw curved arrows to show collapse of the tetrahedral intermediate. || H,C COA H2 COA + в — н ":
Transcribed Image Text:Step 3: Draw curved arrows to show collapse of the tetrahedral intermediate. || H,C COA H2 COA + в — н ":
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