The purinosome contains enzymes that convert the serine hydroxymethylgroup to the formyl group of 10-formyltetrahydrofolate. Write a balancedequation for each reaction in this conversion.
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
The purinosome contains enzymes that convert the serine hydroxymethyl
group to the formyl group of 10-formyltetrahydrofolate. Write a balanced
equation for each reaction in this conversion.
Purinisome is a multi-enzyme complex. It catalyzes the de novo purine nucleotide biosynthesis in the cell. The conversion of serine to glycine is coupled with the transformation of tetrahydrofolate in this biosynthesis.
The serine contains a hydroxymethyl group, while the amino aid glycine contains only hydrogen as a side group.
The conversion of serine to glycine is coupled with tetrahydrofolate (THF) transformation to 5, 10-methylene THF. 5,10-methylene THF is oxidized to form 10-formyl THF. The conversion of serine to 10-formyl THF is as follows:
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