Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
Consider the pyruvate carboxylase reaction, the first bypass step in gluconeogenesis: Pyruvate + CO₂ + ATP = Oxaloacetate + ADP + P₂ Equilibrium concentrations were measured as follows: [pyruvate] =0.451 mM [HCO;] -7.02 mM (note that pCO₂ is represented as [HCO;']) [ATP] = 0.375 mM [oxaloacetate] =0.671 mM [ADP] = 0.963 mM [P] = 11.0 mM a) From the above data, calculate Ke, for the pyruvate carboxylase reaction b) Calculate AG" for this reaction c) Calculate AG under the following conditions: • [pyruvate]- 1.24 mM • [HCO3] = 7.69 mM [ATP] = 1.4 mM [oxaloacetate] =0.001 mM • [ADP]=0.032 mM [P] = 10.0 mm

Consider the pyruvate carboxylase reaction, the first bypass step in gluconeogenesis: Pyruvate + CO₂ + ATP = Oxaloacetate + ADP + P₂ Equilibrium concentrations were measured as follows: [pyruvate] =0.451 mM [HCO;] -7.02 mM (note that pCO₂ is represented as [HCO;']) [ATP] = 0.375 mM [oxaloacetate] =0.671 mM [ADP] = 0.963 mM [P] = 11.0 mM a) From the above data, calculate Ke, for the pyruvate carboxylase reaction b) Calculate AG" for this reaction c) Calculate AG under the following conditions: • [pyruvate]- 1.24 mM • [HCO3] = 7.69 mM [ATP] = 1.4 mM [oxaloacetate] =0.001 mM • [ADP]=0.032 mM [P] = 10.0 mm

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
See similar textbooks
icon
Related questions
Question
100%

My teacher did not go over this really well in class so i'm looking for extra help.

Consider the pyruvate carboxylase reaction, the first bypass step in gluconeogenesis: Pyruvate + CO₂+ ATP Oxaloacetate + ADP + Pi Equilibrium concentrations were measured as follows: [pyruvate] = 0.451 mM [HCO3] = 7.02 mM (note that pCO₂ is represented as [HCO3]) [ATP] = 0.375 mM [oxaloacetate] = 0.671 mM ● • [ADP] = 0.963 mM [Pi] = 11.0 mM a) From the above data, calculate Keq for the pyruvate carboxylase reaction • ● b) Calculate AG for this reaction c) Calculate AG under the following conditions: · [pyruvate] = 1.24 mM [HCO3] = 7.69 mM [ATP] = 1.4 mM [oxaloacetate] = 0.001 mM [ADP] = 0.032 mM [P] = 10.0 mM ● C ZOOM +
Transcribed Image Text:Consider the pyruvate carboxylase reaction, the first bypass step in gluconeogenesis: Pyruvate + CO₂+ ATP Oxaloacetate + ADP + Pi Equilibrium concentrations were measured as follows: [pyruvate] = 0.451 mM [HCO3] = 7.02 mM (note that pCO₂ is represented as [HCO3]) [ATP] = 0.375 mM [oxaloacetate] = 0.671 mM ● • [ADP] = 0.963 mM [Pi] = 11.0 mM a) From the above data, calculate Keq for the pyruvate carboxylase reaction • ● b) Calculate AG for this reaction c) Calculate AG under the following conditions: · [pyruvate] = 1.24 mM [HCO3] = 7.69 mM [ATP] = 1.4 mM [oxaloacetate] = 0.001 mM [ADP] = 0.032 mM [P] = 10.0 mM ● C ZOOM +
Expert Solution
Pyruvate Carboxylase- an important enzyme in gluconeogenesis

Gluconeogenesis is a process by which cells make glucose from non carbohydrate sources. Gluconeogenesis is a very important process to maintain blood glucose concentrations.

When pyruvate is used as precursor for production of glucose, it is first converted to Oxaloacetate (OAA) by an enzyme known as Pyruvate Carboxylase. 

The reaction is:

Pyruvate + HCO3- + ATP ↔ Oxaloacetate + ADP + Pi

trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 4 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON
SEE MORE TEXTBOOKS