Because the degree of DNA methylation appears to be a relatively reliable genetic marker for some forms of cancer, researchers have explored the possibility of altering DNA methylation as a form of cancer therapy. Initial studies indicate that while hypomethylation suppresses the formation of some tumors, other tumors thrive. Why would one expect different cancers to respond differently to either hypomethylation or hypermethylation therapies?

Q: Personalized cancer treatments involve identifying specific pathways in an individual tumor and…

A: Introduction Cancer is defined as a condition which is characterised by uncontrolled mitosis. In…

Q: What is the definition of Driver Mutations & Passenger Mutations? Also describe why each are…

A: A mutation is a change in an organism's DNA sequence. Mutations can occur as a result of errors in…

Q: Which of the following statements are true about the rate of mutation in tumor cells (select all…

A: Chromosome rearrangements, which occur at high rates due to aneuploidy, an aberrant chromosome…

Q: Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is…

A: P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the…

Q: The human genes that convey a susceptibility to hereditary nonpolyposis colorectal cancer are genes…

A: Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is a genetic…

Q: What is the difference between an oncogene and a tumor-suppressor gene? Give some examples of the…

A: Cell proliferation, cell differentiation, and cell survival are under the control of some critical…

Q: Cancer is a major public health problem.  Both inherited genes and environmental factors play a role…

A: Cancer has become a major global health issue for some time. Cancers occur by environmental…

Q: examine the process of gene expression. Include the following: Explain the regulation of gene…

A: Introduction Gene Expression Is The Process Through Which Information From A Gene Is Used To Create…

Q: True/False: When first discovered, investigators found it surprising that some single-gene defects…

A: Immunodeficiencies happen when at least one segments of the safe framework is faulty. The most…

Q: Would the function of KRAS gene be lost or gained in MDA-MB-231 breast cancer derived cells? Please…

A: KRAS gene is a gene present on the short arm of chromosome 12 that is responsible for the formation…

Q: What is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to…

A: Cancer is group of diseases which are characterized by abnormal and unstoppable growth of cell and…

Q: Mutations in proto-oncogenes that turn them into oncogenes tend to be dominant, while cancer-causing…

A: Tumor suppressor genes are the genes that suppress the formation of tumors in the cells or tissues…

Q: Explain why p53 is mutated in the vast majority of human cancers.

A: Any isoform of a protein encoded by homologous genes in multiple animals, such as TP53 and Trp53, is…

Q: Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote…

A: It codes for a protein or a functional product rRNA (ribosomal RNA) or tRNA (transfer RNA). DNA is…

Q: xplain the molecular mechanisms of cancers caused by a P53 gene mutation.

A: cancer may be a disease during which a number of the body’s cells grow uncontrollably and spread to…

Q: The p53 gene is a tumor-suppressor gene while p634  gene is an oncogene. Mutation in either one can…

A: Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts…

Q: Of the following choices a loss of function mutation would most lukely contribute to cancer onset if…

A: Normal DNA contains a particular sequence of DNA. If the sequence of DNA is changed due to external…

Q: Describe how HpaII and MspI can be used to determine if a given DNA sequence is methylated. Any…

A: HpaII and MspI are two useful enzymes used to detect methylation in a given DNA sequence. These…

Q: What separates cancer cells from normal cells?

A:

Q: Create a graph as a better way to display the data in the table 2) Determine which mutations (5q,…

A: Tumorigenesis or oncogenesis refers to the initial formation of cancer, where normal cells is prone…

Q: Patients with XP suffer extremely high incidence of skin cancer but have not been found to have…

A: There are 2 basic types of genetic mutations: Acquired mutations.  These are the most common causes…

Q: What is the difference between a proto-oncogene and a tumor suppressor gene?  How can mutations in…

A: Proto-oncogenes are normally switched off. But when they get activated they cause tumors. On the…

Q: 1). Tumor suppressor proteins monitor DNA and detect damage. Some cancers evade this detection by…

A: Tumor suppressor proteins helps to control cell growth and activated in response to DNA damage and…

Q: What types of evidence indicate that cancer arises from genetic changes?

A: Cancer is a disorder in which abnormal cells divide irrepressibly and destroy the tissues of the…

Cancer Therapy