B cells are specialized blood cells that secrete antibodies. Normally, human blood has millions of differenttypes of B cells making millions of different kinds ofantibody molecules. This variety occurs because, as described in the Fast Forward Box in Chapter 13 entitledProgrammed DNA Rearrangements and the ImmuneSystem, antibody genes undergo rearrangements in theprecursors of B cells. Individual B cell precursorsrearrange their antibody genes in different ways.In the blood of patients with cancers called B celllymphomas, almost all of the antibody molecules areall of one type, but this single type of antibody isdifferent in different lymphoma patients.a. Based on this information, provide a brief description of the genesis of B cell lymphomas, focusingon the cells that are overproliferating.
B cells are specialized blood cells that secrete antibodies. Normally, human blood has millions of different
types of B cells making millions of different kinds of
antibody molecules. This variety occurs because, as described in the Fast Forward Box in Chapter 13 entitled
Programmed DNA Rearrangements and the Immune
System, antibody genes undergo rearrangements in the
precursors of B cells. Individual B cell precursors
rearrange their antibody genes in different ways.
In the blood of patients with cancers called B cell
lymphomas, almost all of the antibody molecules are
all of one type, but this single type of antibody is
different in different lymphoma patients.
a. Based on this information, provide a brief description of the genesis of B cell lymphomas, focusing
on the cells that are overproliferating.

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