The experiment shown in thefigure below uses two strains of mice that differ in their MHC genes. Strain A is H-2a and Strain B is H-2b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2a or H-2b; in each case, the target cells are either uninfected or infected with LCMV. After a four-hour incubation of T cells with target cells, the percentage of target cells lysed by the T cells is shown in the graph. The explanation for the results of this experiment is:Mice of strain B do not make a T cell response to LCMV.Mice of strain A make a more robust T cell response to LCMV than mice of strain B.Target cells that express H-2b cannot be infected with LCMV.T cells from mice of strain A only recognize viral peptides on target cells expressing H-2a. LCMV peptides do not bind to MHC class I molecules from H-2b mice. Mouse AMouse Blymphocyticchoriomenigitisvirus (LCM)MHC-H-2aMHC-H-2bI cellsI cellsTarget cells: H-2aTarget cells: H-2b100-75–8 50-25-0.I cells fromI cells frommouse Bmouse ALCMV-infected H-2ª target cellsuninfected H-2ª target cellsLCMV-infected H-2° target cellsuninfected H-2° target cellstotal cell killing (%)

An efficient adaptive immune system requires the TCR's capacity to distinguish aliens from…

Answered: The experiment shown in thefigure below…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

See similar textbooks

Related questions

Concept explainers

Question

The experiment shown in thefigure below uses two strains of mice that differ in their MHC genes. Strain A is H-2^aand Strain B is H-2^b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2^aor H-2^b; in each case, the target cells are either uninfected or infected with LCMV. After a four-hour incubation of T cells with target cells, the percentage of target cells lysed by the T cells is shown in the graph. The explanation for the results of this experiment is:

Mice of strain B do not make a T cell response to LCMV.
Mice of strain A make a more robust T cell response to LCMV than mice of strain B.
Target cells that express H-2^b cannot be infected with LCMV.
T cells from mice of strain A only recognize viral peptides on target cells expressing H-2^a.
LCMV peptides do not bind to MHC class I molecules from H-2^b mice.

Mouse A
Mouse B
lymphocytic
choriomenigitis
virus (LCM)
MHC-H-2a
MHC-H-2b
I cells
I cells
Target cells: H-2a
Target cells: H-2b
100-
75–
8 50-
25-
0.
I cells from
I cells from
mouse B
mouse A
LCMV-infected H-2ª target cells
uninfected H-2ª target cells
LCMV-infected H-2° target cells
uninfected H-2° target cells
total cell killing (%)

Expert Solution

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions