After performing analysis of whole genome sequencing from a candidate that grew on SC-H in the initial screen, you are unable to identify a causative mutation. Which of the following options is a likely explanation for why this mutant passed the initial screen? Select all that apply. The causative mutation lies in a sequence coverage gap. One of the missense mutations you analyzed is actually causative, but the factor has not been previously linked to transcription. The mutation is a truncation mutation and Illumina sequencing only provides information for missense mutations. The mutation is in a hypothetical protein and uncategorized genes cannot be sequenced by Illumina technology.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
After performing analysis of whole genome sequencing from a candidate that grew on SC-H in the initial screen, you are unable to identify a causative mutation. Which of the following options is a likely explanation for why this mutant passed the initial screen? Select all that apply.
The causative mutation lies in a sequence coverage gap.
One of the missense mutations you analyzed is actually causative, but the factor has not been previously linked to transcription.
The mutation is a truncation mutation and Illumina sequencing only provides information for missense mutations.
The mutation is in a hypothetical protein and uncategorized genes cannot be sequenced by Illumina technology.
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